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Table 2 A Comparison of Outcomes in the Cerebrolysin and Saline Groups

From: Randomized, placebo-controlled, double-blind, pilot trial to investigate safety and efficacy of Cerebrolysin in patients with aneurysmal subarachnoid hemorrhage

 

Cerebrolysin

n = 25

Normal Saline

n = 25

OR (95% CI)

Global Functional Outcome at 6 months

 GOSE, median (IQR)

7 (5–8)

7 (3–8)

NS

 GOSE, favorable outcome, i.e. 5–8

19

17

NS

 mRS, median (IQR)

1 (0–3)

2 (0–4)

NS

 mRS, favorable outcome, i.e. 0–3

22

17

NS

 BI, mean + SD

91 + 28

90 + 24

NS

 BI > 75

23

18

NS

Global Functional Outcome at 3 months

  

NS

 GOSE, median (IQR)

5 (4–6)

6 (3–7)

 

 GOSE, favorable outcome, i.e. 5–8

15

16

NS

 mRS, median (IQR)

2 (2–4)

2 (2–5)

NS

 mRS, favorable outcome, i.e. 0–3

18

17

NS

Mortality

 6-month

0

4

0.46 (0.33–0.63)

 3-month

0

4

0.46 (0.33–0.63)

 30-day

0

3

NS

Delayed Cerebral Ischemia

11

12

NS

Cerebral Vasospasm

3

7

NS

Cerebral infarction

14

15

NS

Neurocognitive Performance at 6 months

 MOCA, mean + SD

21 + 9

21 + 8

NS

 NCSE, within average range

  Orientation

20

18

NS

  Attention

21

18

NS

  Language comprehension

18

16

NS

  Repetition

15

10

NS

  Naming

11

3

4.71 (1.10–20.00)

  Constructional ability

19

15

NS

  Memory

12

9

NS

  Calculation

19

17

NS

  Reasoning

18

10

2.83 (1.01–9.61)

  Judgment

19

18

NS

Quality of Life at 6 months

 SF-36®

  Physical health score, mean + SD

77 + 23

74 + 26

NS

  Mental health score, mean + SD

69 + 25

69 + 21

NS

 SS-QoL, mean + SD

4.5 + 0.7

4.5 + 0.6

NS

  Physical subscore, mean + SD

4.6 + 0.8

4.5 + 0.7

NS

  Psychosocial subscore, mean + SD

4.2 + 0.9

4.4 + 0.6

NS

Adverse Effects

0

0

NS

Length of Hospital Stay, mean + SD

33 + 15

39 + 32

NS

  1. OR odds ratio, CI confidence interval, mRS modified Rankin score, GOSE extended Glasgow outcome score, IQR interquartile range, SD standard deviation, BI modified Barthel index, MOCA Montreal cognitive assessment, NCSE Neurobehavioral cognitive state examination, SF-36® Short-form 36 Health Survey, SS-QoL stroke-specific quality of life, NS not significant