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Table 2 Differences in clinical characteristics and baseline imaging profiles according to dichotomized clinical course based on malignant progression

From: Optic nerve sheath diameter change in prediction of malignant cerebral edema in ischemic stroke: an observational study

  Malignant progressors
(n = 19)
Nonprogressors
(n = 39)
P-value
Clinical characteristics
 Sex, male 9 (47.4%) 22 (56.4%) 0.517
 Age 65 ± 19 69 ± 13 0.407
 Hypertension 15 (75.0%) 24 (60.0%) 0.251
 Diabetes mellitus 8 (40.0%) 10 (25.0%) 0.232
 Onset to door (min) 195 ± 240 173 ± 182 0.511
 Hypothermia 10 (52.6%) 21 (53.8%) 0.931
 Thrombolysis 12 (63.2%) 29 (74.4%) 0.379
 Endovascular treatment 19 (100.0%) 29 (74.4%) 0.015
 Successful reperfusion 11 (57.9%) 22 (56.4%) 0.915
 Outcomes (3 month mRS)    0.014
  0 0 (0.0%) 2 (5.1%)  
  1 0 (0.0%) 2 (5.1%)  
  2 0 (0.0%) 5 (12.8%)  
  3 1 (5.3%) 4 (10.3%)  
  4 2 (10.5%) 10 (25.6%)  
  5 3 (15.8%) 9 (23.1)  
  6 13 (68.4%) 7 (17.9%)  
CTbaseline
 CT angiography occlusion    0.015
  Complex T 10 (52.6%) 6 (15.4%)  
  Simple T 4 (21.1%) 11 (28.2%)  
  MCA M1 3 (15.8%) 14 (35.9%)  
  Tandem 0 (0.0%) 7 (17.9%)  
  Proximal ICA 1 (5.3%) 0 (0.0%)  
  Dissection 1 (5.3%) 1 (2.6%)  
 Initial DWI volume (ml) 237 ± 109 144 ± 43 0.002
 ONSD (mm) 5.17 ± 0.55 5.37 ± 0.63 0.233
 ONSD/ETD ratio 22.84 ± 2.33% 23.60 ± 2.83% 0.316
 MLS (mm) 0.44 ± 0.78 0.37 ± 0.95 0.789
  1. Values are presented as mean ± SD, number (%), or median (interquartile range)
  2. mRS Modified Rankin Scale, CT Computed tomography, MCA Middle cerebral artery, ICA Internal carotid artery, DWI Diffusion weighted images, ONSD Optic nerve sheath diameter, ETD Eyeball transverse diameter, MLS Midline shift