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Table 1 Demographic and clinical characteristics of patients with and without MCE

From: A web based dynamic MANA Nomogram for predicting the malignant cerebral edema in patients with large hemispheric infarction

Parameter Non-ME (N = 101) ME (N = 41) P
Age, y, (IQR) 58 (51 ~ 67) 64 (57 ~ 71) 0.005*
Gender, male, N (%) 70 (69.3) 26 (63.4) 0.497
Smoke, N (%) 53 (52.5) 21 (51.2) 0.892
Drink, N (%) 44 (43.6) 14 (34.1) 0.302
Hypertension, N (%) 50 (49.5) 21 (51.2) 0.853
Diabetes mellitus, N (%) 18 (17.8) 9 (22) 0.570
Previous stroke, N (%) 16 (15.8) 13 (31.7) 0.037*
Preexisting coronary heart disease, N (%) 9 (8.9) 10 (24.4) 0.018*
KAF 8 (7.9) 13 (31.7) 0.001*
Treatment, N (%)
 Conservative (reference) 79 (78.2) 34 (82.9)  
 Intravenous thrombolysis 16 (15.8) 4 (9.8) 0.362
 Endovascular intervention 6 (5.9) 3 (7.3) 0.839
NIHSS (IQR) 18 (15 ~ 20) 21 (20 ~ 22) <  0.001*
MLS, mm (IQR) 1.9 (3.6 ~ 5.1) 5.6 (4.9 ~ 8.1) <  0.001*
Baseline temperature, °C (IQR) 36.5 (36.4 ~ 36.8) 36.5 (36.5 ~ 37.1) 0.170
ACA territory involvement, N (%) 9 (8.9) 18 (43.9) <  0.001*
PCA territory involvement, N (%) 27 (26.7) 24 (58.5) <  0.001*
Basal ganglia involvement, N (%) 60 (59.4) 37 (90.2) 0.001*
Cerebral hemisphere, right, N (%) 56 (55.4) 15 (36.6) 0.044*
Systolic pressure, mmHg, (IQR) 145 (127 ~ 166) 141 (120 ~ 159) 0.168
Diastolic pressure, mmHg, (IQR) 83 (73 ~ 95) 80 (74 ~ 92) 0.871
FBG, mmol/L, (IQR) 5.9 (5.4 ~ 6.8) 7.1 (5.8 ~ 9.2) 0.002*
HbA1c, %, (IQR) 5.6 (5.3 ~ 6.1) 5.7 (5.3 ~ 6.1) 0.378
  1. MCE: Malignant cerebral edema, IQR Interquartile range, KAF Previously known atrial fibrillation, NIHSS National Institutes of Health stroke scale, MLS Midline shift, ACA Anterior cerebral artery, PCA Posterior cerebral artery, FBG Baseline fasting blood glucose, HbA1c Glycosylated hemoglobin
  2. *p < 0.05 in univariate analysis were included in multivariable logistic regression models for adjustment