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Table 1 Demographics

From: Detection of gray matter microstructural changes in Alzheimer’s disease continuum using fiber orientation

  CN (n = 78) EMCI (n = 50) EMCI Non-converter (n = 38) EMCI Converter
(n = 12)
LMCI (n = 34) AD (n = 39) Post hoc
Female, n (%) 42 (53.8) 19 (37.2) 14 (36.8) 5 (41.7) 15 (44.1) 17 (43.6)
Age (SD) (y) 72.7 ± 5.9 74.7 ± 5.3 74.1 ± 4.9 76.4 ± 4.7 73.9 ± 5.6 74.7 ± 7.2
Education (SD) (y) 16.7 ± 2.5 15.2 ± 2.6 15.0 ± 2.5 15.6 ± 3.1 16.1 ± 2.8 15.4 ± 2.9
GCDR (SD) 0.0 0.5 0.5 0.5 0.5 0.8 ± 0.3 CN < EMCI = LMCI<AD
MMSE (SD) 29.3 ± 1.5 28.2 ± 1.2 28.3 ± 1.1 28.1 ± 1.7 27.6 ± 1.4 24.4 ± 4.0 CN > EMCI = LMCI>AD
MADAS-Cog (SD) 9.7 ± 6.8 13.6 ± 5.9 13.2 ± 5.0 14.5 ± 4.9 14.6 ± 4.8 26.3 ± 14.2 CN < EMCI = LMCI<AD
Immediate recall (SD) 14.2 ± 2.9 10.4 ± 3.4 10.5 ± 3.6 9.9 ± 2.7 6.4 ± 3.3 3.8 ± 2.0 CN > EMCI>LMCI>AD
Delayed recall (SD) 12.8 ± 3.4 8.6 ± 2.0 8.6 ± 2.1 8.7 ± 1.6 3.1 ± 2.7 1.3 ± 1.6 CN > EMCI>LMCI>AD
MRI center 30/48 40/10 29/9 11/1 28/6 36/3
Florbetapir+, n (%) 0 (0) 50 (100) 38 (100) 12 (100) 34 (100) 39 (100)
AV1451 image, n (%) 44 (68.8) 9 (14.1) 8 (21.1) 1 (8.33) 5 (7.8) 3 (4.7)
  1. Data are n (%) or mean ± SD values. There were no gender, age, or year of education intergroup differences. GCDR, MMSE, and MADAS-Cog scores in EMCI and LMCI did not show significant differences. Analysis of variance with Tukey test was used for post hoc analysis with p < 0.05. For MRI data, two major scanners were used: GE and SIEMENS and delineated as MRI center GE/SIEMENS
  2. AD Alzheimer’s disease, CN Cognitively normal, EMCI Early mild cognitive impairment, GCDR Global Clinical Dementia Rating, LMCI Late mild cognitive impairment, MADAS-Cog Modified Alzheimer’s Disease Assessment Scale-Cognitive subscale, MMSE Mini Mental State Examination