Fig. 3

MRI of Case 6 showing coexistence of tumefactive and BCS-type lesions. At symptom onset a tumefactive lesion with incomplete ring Gd + in the right optic radiation-parietal lobe (A and C arrowhead) and multiple lesions (B); 14 with Gd + (D). A BCS-type lesion with incomplete ring Gd + (E and F thick arrow) in the right corona radiata evolved at a 2-months follow-up. BCS-type (H thick arrow) and tumefactive (G arrowhead) lesions at month 6 after rituximab initiation, one year from the first clinical episode. a, b, e, g, h: 3D FLAIR images. c, d, f: 3D T1-weighted contrast-enhanced images. BCS: Baló’s concentric sclerosis, Gd+: gadolinium enhancement