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Table 1 Baseline characteristics of patients under GA and CS

From: Effect of anesthesia strategy during endovascular therapy on 90-day outcomes in acute basilar artery occlusion: a retrospective observational study

Variable name

Overall (n = 178)

GA (n = 139)

CS (n = 39)

P

Demographic data

 Age, mean (SD), years

60 (10)

60 (10)

60 (11)

0.96

 Male sex

150 (84.3)

121 (87.1)

29 (74.4)

0.05

Vascular risk factors

 Hypertension

125 (70.2)

99 (71.2)

26 (66.7)

0.58

 Diabetes mellitus

50 (28.1)

41 (29.5)

9 (23.1)

0.43

 Dyslipidemia

29 (16.3)

26 (18.7)

3 (7.7)

0.14

 Coronary heart disease

21 (11.8)

16 (11.5)

5 (12.8)

0.78

 Previous ischemic stroke

36 (20.2)

24 (17.3)

12 (30.8)

0.07

 Current smoking

66 (37.1)

52(37.4)

14 (35.9)

0.86

Clinical characteristics

 Mode of stroke onset

   

0.08

  Acute

88 (49.4)

67 (48.2)

21(53.8)

 

  Progressive

82 (46.1)

68 (48.9)

14 (35.9)

 

 Fluctuating

8 (4.5)

4 (2.9)

4 (10.3)

 

 Pre-procedural SBP, mean (SD),mmHg

160(25)

160(26)

160 (24)

0.86

 Post-procedural SBP, mean (SD),mmHg

144 (21)

143 (22)

146 (19)

0.57

 NIHSS score, median (IQR)

20.5 (10–33)

22 (11–35)

16(6–30)

0.04

 mRS before stroke, median (IQR)

0 (0–0)

0 (0–0)

0 (0–0)

0.30

 WBCs, mean (SD), ×1 09

10.8 (3.8)

11.0 (3.7)

10.3 (4.0)

0.29

 Blood glucose, mean (SD), mmol/L

8.8 (3.5)

8.6 (3.2)

9.8 (4.4)

0.05

 Creatinine, mean (SD), umol/L

70.0 (21.7)

71.5 (20.7)

64.8 (24.7)

0.10

 pc-ASPECTS on DWI, median (IQR)

6 (5–8)

7 (5–8)

6 (4–8)

0.81

 PMI on DWI, median (IQR)

2 (0–4)

2 (0.25–4)

2 (0–3)

0.58

 Occlusion site

   

0.99

  Proximal BA

100 (56.2)

78 (56.1)

22 (56.4)

 

  Middle BA

51 (28.7)

40 (28.8)

11 (28.2)

 

  Distal BA

27 (15.2)

21 (15.1)

6 (15.4)

 

 Tandem lesion

24 (13.5)

17 (12.2)

7 (17.9)

0.36

 Underlying ICAS

111 (62.4)

89 (64.0)

22 (56.4)

0.39

 ASITN/SIR collateral system

   

0.68

  Grade 0–1

76 (42.7)

61 (43.9)

15 (38.5)

 

  Grade 2

81 (45.5)

63 (45.3)

18 (46.2)

 

  Grade 3–4

21 (11.8)

15 (10.8)

6 (15.4)

 

 Stroke subtype by TOAST criteria

   

0.82

  Large artery arteriosclerosis

143 (80.3)

112 (80.6)

31 (79.5)

 

  Cardioembolic

28 (15.7)

21 (15.1)

7 (17.9)

 

  Other or unknown etiology

7 (3.9)

6 (4.3)

1 (2.6)

 

Procedural features

 Prior use of intravenous tPA

35 (19.7)

26 (18.7)

9 (23.1)

0.54

 Use of Solitaire retriever

130 (73.0)

110 (79.1)

20 (51.3)

< 0.01

 No. of passes, median (IQR)

1 (1–2)

1 (1–2)

1 (1–2)

0.44

 Intra-arterial tPA or Urokinase

40(22.5)

29 (20.9)

11 (28.2)

0.33

 Infusion of Tirofiban

123 (69.1)

102 (73.4)

21 (53.8)

0.02

 Heparinization

76 (42.7)

60 (43.2)

16 (41.0)

0.81

 Angioplasty

   

< 0.01

  No

57 (32.0)

36 (25.9)

21 (53.8)

 

  Balloon alone

31 (17.4)

25 (18.0)

6 (15.4)

 

  stenting

90 (50.6)

78 (56.1)

12 (30.8)

 

 OTP, median (IQR), hours

7 (5–10)

7 (5–10)

7 (5–13)

0.71

 PTR, median (IQR), hours

1(0.5–2)

1(0.5–2)

1(0.5–2)

0.34

 Anesthesia time (IQR), hours

1.5 (1–2)

1.5 (1–2)

1 (1–2)

0.01

 Successful recanaliation (mTICI 2b-3)

151 (84.8)

118 (84.9)

33 (84.6)

0.97

  1. Values are numbers with percentages in parentheses, unless indicated otherwise
  2. GA indicates general anesthesia, CS conscious sedation, SD standard deviation, SBP systolic blood pressure, NIHSS National Institutes of Health Stroke Scale, mRS modified Rankin Scale, WBC white blood cell, IQR interquartile range, pc-ASPECTS posterior circulation Acute Stroke Prognosis Early CT Score, DWI diffusion weighted imaging, PMI Pons-Midbrain Index, BA basilar artery, ICAS intracranial atherosclerotic stenosis, ASITN/SIR American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology, TOAST Trial of Org 10,172 in Acute Stroke Treatment, tPA tissue plasminogen activator, OTP onset-to-puncture time, PTR puncture to recanalization time, mTICI modified Thrombolysis In Cerebral Infarction scale