Table 1 Expected precision of the estimate of recurrence, based on a range of sample sizes and recurrence rates, after allowing for 10% loss to follow-up by the end of the one- year period. These are based on exact confidence intervals for the proportion of recurrences, using the Clopper-Pearson method
Sample size | Estimated margin of error (%) | ||||||
|---|---|---|---|---|---|---|---|
Total number of participants recruited to trial 2 | Total number of trial 2 participants followed-up | Recurrence rate (%) | |||||
10 | 15 | 20 | 25 | 30 | 35 | ||
30 | 27 | 13.4 | 14.8 | 15.9 | 17.6 | 18.2 | 18.7 |
35 | 32 | 11.5 | 13.8 | 14.6 | 16.0 | 16.5 | 17.3 |
40 | 36 | 11.5 | 12.4 | 13.9 | 15.0 | 15.9 | 16.5 |
45 | 41 | 10.2 | 11.8 | 13.0 | 14.0 | 14.7 | 15.3 |
50 | 45 | 10.2 | 11.5 | 12.5 | 13.3 | 14.2 | 14.7 |
55 | 50 | 9.2 | 10.5 | 11.8 | 12.6 | 13.4 | 13.8 |
60 | 54 | 8.6 | 10.3 | 11.4 | 12.3 | 12.8 | 13.3 |
65 | 59 | 8.5 | 9.9 | 10.9 | 11.7 | 12.3 | 12.7 |
70 | 63 | 8.0 | 9.3 | 10.6 | 11.3 | 11.9 | 12.3 |
75 | 68 | 7.9 | 9.1 | 10.2 | 10.8 | 11.4 | 11.9 |
80 | 72 | 7.5 | 8.9 | 9.7 | 10.5 | 11.1 | 11.5 |