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Fig. 2 | BMC Neurology

Fig. 2

From: Malignant transformation of pleomorphic xanthoastrocytoma and differential diagnosis: case report

Fig. 2

Microscopic findings of tumors in the initial and recurrent specimens. Spindle cells with nuclear atypia (arrows) with diffusely infiltrating lymphocytes, and eosinophilic granular bodies (arrow heads) as seen in the first resection. (hematoxylin and eosin (H&E) stain, a × 200, b and c × 400). In the recurrent specimen, broad necrosis and infiltrating tumor cells can be observed, and massively increased cellularity and prominent atypia are present along the relatively well-defined border line (d and e, H&E stain, × 200). With microvascular proliferation, only a small proportion of spindle shape cells (arrows) and xantic cells (arrow heads) can be observed, implying similarity to the previous resection (f, H&E stain, × 400). Multiple mitoses are visible (black arrows), indicating malignancy (g, H&E stain, × 400). No reticulin fibers were observed in the first (h) and second (i) specimens (reticulin stain, × 200). On CD34 staining, tumor cells were not stained in the first (j) and second (k) specimens (CD34 stain, × 200)

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