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Table 2 Genetic comparison among the different disease entities

From: Malignant transformation of pleomorphic xanthoastrocytoma and differential diagnosis: case report

 GBM (wild type)E-GBMPXAAPXAPresent case
(1st resection)
Present case
(2nd resection)
1p/19qNANANANAIntact1p; intact,
19q; deletion
BRAF V600E7.7~9.1% [6, 10]16.6~93% [11, 13, 14]63~75% [1, 7]46.2~57% [1, 3]Positive (MAF, 16%)Positive (MAF, 49%)
CDKN2A/B homozygous deletionNA79% [11]60~83% [2, 8]93% [7]IntactPositive
TERT promoter mutation54% [11]71% [11]4% [11]23% [11]NegativeNegative
  1. GBM glioblastoma, E-GBM epithelioid glioblastoma, PXA pleomorphic xanthoastrocytoma, APXA anaplastic PXA, MAF mutant allele frequency, NA not available