Safety and tolerability of monthly galcanezumab injections in patients with migraine: integrated results from migraine clinical studies

Table 11 Percentage of patients in integrated double-blind studies reporting treatment-emergent changes to blood pressure and pulse

Abbreviations: bpm Beats per minute, N Number of patients in the analysis population, n Number of patients within each specific category, PCS Possibly clinically significant
^aFor systolic blood pressure: treatment-emergent low ≤90 mmHg with ≥20 mmHg decrease; treatment-emergent high ≥140 mmHg with ≥20 mmHg increase; PCS high ≥180 mmHg with ≥20 mmHg increase; sustained elevation ≥140 mmHg with ≥20 mmHg increase for 2 consecutive office visits
^bFor diastolic blood pressure: treatment-emergent low ≤50 mmHg with ≥10 mmHg decrease; treatment-emergent high ≥90 mmHg with ≥10 mmHg increase; PCS high ≥105 mmHg with ≥15 mmHg increase; sustained elevation ≥90 mmHg with ≥10 mmHg increase for 2 consecutive office visits
^cFor pulse: treatment-emergent low < 50 bpm with ≥15 bpm decrease; treatment-emergent high > 100 bpm with ≥15 bpm increase; sustained elevation > 100 bpm with ≥15 bpm increase for 2 consecutive office visits

ISSN: 1471-2377