From: CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study
SNP ID | Model | Genotype | Male | Female | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR (95%CI) | p | Case | Control | OR (95%CI) | p | |||
CYP3A4 rs4646440 | Allele | G | 509 | 492 | 1.00 | 0.050 | 259 | 262 | 1.00 | 0.563 |
A | 123 | 156 | 0.76 (0.58–1.00) | 63 | 72 | 0.89 (0.61–1.29) | ||||
Genotype | GG | 202 | 183 | 1.00 | 0.117 | 105 | 99 | 1.00 | 0.226 | |
GA | 105 | 126 | 0.74 (0.53–1.05) | 0.089 | 49 | 64 | 0.69 (0.43–1.11) | 0.123 | ||
AA | 9 | 15 | 0.53 (0.22–1.27) | 0.156 | 7 | 4 | 1.44 (0.40–5.15) | 0.576 | ||
Dominant | GG | 202 | 183 | 1.00 | 0.052 | 105 | 99 | 1.00 | 0.188 | |
GA-AA | 114 | 141 | 0.72 (0.52–1.00) | 56 | 68 | 0.74 (0.47–1.16) | ||||
Recessive | GG-GA | 307 | 309 | 1.00 | 0.237 | 154 | 163 | 1.00 | 0.438 | |
AA | 9 | 15 | 0.60 (0.25–1.41) | 7 | 4 | 1.65 (0.47–5.81) | ||||
Log-additive | – | – | – | 0.74 (0.56–0.98) | 0.038 | – | – | 0.83 (0.56–1.24) | 0.371 | |
CYP11A1 rs12912592 | Allele | G | 565 | 602 | 1.00 | 0.081 | 297 | 301 | 1.00 | 0.672 |
T | 67 | 50 | 1.43 (0.97–2.10) | 25 | 29 | 0.87 (0.50–1.53) | ||||
Genotype | GG | 250 | 277 | 1.00 | 138 | 136 | 1.00 | |||
GT | 65 | 48 | 1.58 (1.04–2.42) | 0.034 | 21 | 29 | 0.64 (0.34–1.19) | 0.161 | ||
TT | 1 | 1 | 0.63 (0.04–10.19) | 0.743 | 2 | 0 | / | / | ||
Dominant | GG | 250 | 277 | 1.00 | 0.039 | 138 | 136 | 1.00 | 0.224 | |
GT-TT | 66 | 49 | 1.56 (1.02–2.37) | 23 | 29 | 0.70 (0.38–1.28) | ||||
Recessive | GG-GT | 315 | 325 | 1.00 | 0.704 | 159 | 165 | 1.00 | / | |
TT | 1 | 1 | 0.58 (0.04–9.45) | 2 | 0 | / | ||||
Log-additive | – | – | – | 1.51 (1.00–2.28) | 0.051 | – | – | 0.78 (0.44–1.38) | 0.393 |