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Table 4 Relationships between CYP3A54 and CYP11A1 polymorphism and ischemic stroke risk according to the stratification by gender

From: CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study

SNP IDModelGenotypeMaleFemale
CaseControlOR (95%CI)pCaseControlOR (95%CI)p
CYP3A4
rs4646440
AlleleG5094921.000.0502592621.000.563
A1231560.76 (0.58–1.00)63720.89 (0.61–1.29)
GenotypeGG2021831.000.117105991.000.226
GA1051260.74 (0.53–1.05)0.08949640.69 (0.43–1.11)0.123
AA9150.53 (0.22–1.27)0.156741.44 (0.40–5.15)0.576
DominantGG2021831.000.052105991.000.188
GA-AA1141410.72 (0.52–1.00)56680.74 (0.47–1.16)
RecessiveGG-GA3073091.000.2371541631.000.438
AA9150.60 (0.25–1.41)741.65 (0.47–5.81)
Log-additive0.74 (0.56–0.98)0.0380.83 (0.56–1.24)0.371
CYP11A1
rs12912592
AlleleG5656021.000.0812973011.000.672
T67501.43 (0.97–2.10)25290.87 (0.50–1.53)
GenotypeGG2502771.00 1381361.00 
GT65481.58 (1.04–2.42)0.03421290.64 (0.34–1.19)0.161
TT110.63 (0.04–10.19)0.74320//
DominantGG2502771.000.0391381361.000.224
GT-TT66491.56 (1.02–2.37)23290.70 (0.38–1.28)
RecessiveGG-GT3153251.000.7041591651.00/
TT110.58 (0.04–9.45)20/
Log-additive1.51 (1.00–2.28)0.0510.78 (0.44–1.38)0.393
  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustments for age and gender
  3. p < 0.05 indicates statistical significance
  4. Bold indicates that the values have statistical significance