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Table 4 Relationships between CYP3A54 and CYP11A1 polymorphism and ischemic stroke risk according to the stratification by gender

From: CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study

SNP ID

Model

Genotype

Male

Female

Case

Control

OR (95%CI)

p

Case

Control

OR (95%CI)

p

CYP3A4

rs4646440

Allele

G

509

492

1.00

0.050

259

262

1.00

0.563

A

123

156

0.76 (0.58–1.00)

63

72

0.89 (0.61–1.29)

Genotype

GG

202

183

1.00

0.117

105

99

1.00

0.226

GA

105

126

0.74 (0.53–1.05)

0.089

49

64

0.69 (0.43–1.11)

0.123

AA

9

15

0.53 (0.22–1.27)

0.156

7

4

1.44 (0.40–5.15)

0.576

Dominant

GG

202

183

1.00

0.052

105

99

1.00

0.188

GA-AA

114

141

0.72 (0.52–1.00)

56

68

0.74 (0.47–1.16)

Recessive

GG-GA

307

309

1.00

0.237

154

163

1.00

0.438

AA

9

15

0.60 (0.25–1.41)

7

4

1.65 (0.47–5.81)

Log-additive

0.74 (0.56–0.98)

0.038

0.83 (0.56–1.24)

0.371

CYP11A1

rs12912592

Allele

G

565

602

1.00

0.081

297

301

1.00

0.672

T

67

50

1.43 (0.97–2.10)

25

29

0.87 (0.50–1.53)

Genotype

GG

250

277

1.00

 

138

136

1.00

 

GT

65

48

1.58 (1.04–2.42)

0.034

21

29

0.64 (0.34–1.19)

0.161

TT

1

1

0.63 (0.04–10.19)

0.743

2

0

/

/

Dominant

GG

250

277

1.00

0.039

138

136

1.00

0.224

GT-TT

66

49

1.56 (1.02–2.37)

23

29

0.70 (0.38–1.28)

Recessive

GG-GT

315

325

1.00

0.704

159

165

1.00

/

TT

1

1

0.58 (0.04–9.45)

2

0

/

Log-additive

1.51 (1.00–2.28)

0.051

0.78 (0.44–1.38)

0.393

  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustments for age and gender
  3. p < 0.05 indicates statistical significance
  4. Bold indicates that the values have statistical significance