CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study

BMC Neurology

Table 6 Haplotype frequencies and their associations with ischemic stroke risk

Gene	SNP	Haplotype	Frequency		Crude analysis		Adjusted by age and gender
Gene	SNP	Haplotype	Case	Control	OR (95% CI)	p	OR (95% CI)	p
CYP3A4	rs4646440\|rs35564277	GT	0.805	0.768	1		1
	rs4646440\|rs35564277	AT	0.138	0.159	0.82 (0.63–1.06)	0.130	0.78 (0.60–1.02)	0.070
	rs4646440\|rs35564277	AC	0.058	0.072	0.79 (0.55–1.12)	0.190	0.75 (0.52–1.08)	0.120
CYP11A1	rs1484215\|rs12912592\|rs28681535	CGT	0.430	0.446	1		1
	rs1484215\|rs12912592\|rs28681535	CGG	0.294	0.290	1.07 (0.87–1.31)	0.550	1.06 (0.85–1.31)	0.600
	rs1484215\|rs12912592\|rs28681535	TGG	0.180	0.184	1.01 (0.79–1.29)	0.940	1.06 (0.82–1.37)	0.670
	rs1484215\|rs12912592\|rs28681535	CTG	0.096	0.080	1.29 (0.92–1.81)	0.130	1.24 (0.87–1.75)	0.230

CYP3A4 block comprises the two closely linked SNPs rs4646440 and rs35564277. CYP11A14 block comprises the three closely linked SNPs rs1484215, rs12912592, and rs28681535
OR odds ratio, 95% CI 95% confidence interval
p values were calculated using logistic regression analysis with and without adjustment by gender and age

ISSN: 1471-2377