Table 2 Demographic and clinical features of the SCA3 patients with and without each type of abnormal eye movement

Sex (male,%)^c

10 (47.6%)

29 (54.7%)

0.693

2 (20.0%)

37 (57.8%)

0.727

31 (53.4%)

8 (50.0%)

0.807

Mean age (years)^a

45.05 ± 12.47

45.04 ± 11.90

0.919

43.20 ± 9.81

45.33 ± 12.32

0.789

43.81 ± 11.66

49.50 ± 12.40

0.215

Age of onset (years)^a

37.38 ± 11.78

39.35 ± 12.88

0.693

37.20 ± 9.40

39.04 ± 12.99

0.789

38.03 ± 11.62

41.56 ± 15.49

0.222

Disease duration (years)^b

7.67 ± 5.30

5.69 ± 6.54

0.200

6.00 ± 5.54

6.29 ± 6.38

0.885

5.78 ± 4.10

7.94 ± 11.04

0.760

Educational year^b

10.00 ± 4.04

10.74 ± 4.72

0.688

9.20 ± 3.36

10.73 ± 4.66

0.789

11.03 ± 4.57

8.69 ± 3.93

0.089

BMI^b

20.81 ± 2.63

24.83 ± 25.28

0.693

21.15 ± 3.38

24.08 ± 23.04

0.885

21.07 ± 2.99

33.16 ± 45.67

0.241

Hyperreflexia^c

10 (47.6%)

23 (43.4%)

0.824

6 (60%)

27 (42.2%)

0.789

30 (51.7%)

3 (18.8%)

0.067

Vision loss^c

9 (42.9%)

15 (28.3%)

0.429

6 (60.0%)

18 (28.1%)

0.727

22 (37.9%)

2 (12.5%)

0.133

ICARS-I^d

14.91 ± 7.25

11.23 ± 6.24

0.223

11.20 ± 4.37

12.44 ± 7.01

0.789

12.93 ± 6.30

9.88 ± 7.74

0.055

ICARS-II^d

19.38 ± 10.12

14.23 ± 8.12

0.165

13.00 ± 8.54

16.11 ± 9.03

0.789

16.38 ± 8.75

13.19 ± 9.59

0.067

ICARS-III^d

2.43 ± 1.78

1.76 ± 1.40

0.398

1.50 ± 1.35

2.02 ± 1.56

0.789

1.95 ± 1.48

1.94 ± 1.77

0.722

ICARS-IV^d

3.05 ± 1.43

1.93 ± 1.27

0.060

2.90 ± 1.60

2.14 ± 1.36

0.727

2.55 ± 1.27

1.13 ± 1.31

0.020*

Total ICARS score^d

39.76 ± 18.04

29.13 ± 14.68

0.113

28.60 ± 14.14

32.70 ± 16.65

0.789

33.81 ± 15.39

26.13 ± 18.58

0.040*

SARA score^d

13.79 ± 6.17

9.91 ± 5.21

0.113

9.70 ± 3.74

11.21 ± 5.98

0.789

11.41 ± 5.35

9.56 ± 6.94

0.133

MoCA score^e

22.28 ± 5.33

24.06 ± 4.36

0.398

24.00 ± 2.00

23.52 ± 4.98

0.789

24.28 ± 4.20

21.06 ± 5.58

0.241

HDRS-24 score^b

9.00 ± 8.16

8.72 ± 9.28

0.683

6.50 ± 3.75

9.16 ± 9.45

0.885

9.55 ± 9.60

6.06 ± 5.17

0.396

HARS score^b

6.76 ± 4.79

6.85 ± 7.80

0.429

4.80 ± 4.42

7.14 ± 7.34

0.789

7.66 ± 7.60

3.81 ± 3.08

0.215

ESS score^b

5.33 ± 5.03

5.43 ± 4.57

0.867

6.30 ± 5.60

5.27 ± 4.55

0.789

5.59 ± 4.67

4.75 ± 4.77

0.608

PSQI score^b

8.33 ± 4.09

6.79 ± 4.56

0.280

6.00 ± 2.98

7.42 ± 4.64

0.789

7.36 ± 4.57

6.75 ± 4.14

0.722

CAG repeat length^b

64.19 ± 13.22

66.81 ± 10.27

0.693

69.70 ± 3.23

65.50 ± 11.84

0.789

68.48 ± 7.33

57.31 ± 17.22

0.040*

Yes

(n = 31)

No

(n = 43)

P value

Yes

(n = 17)

No

(n = 57)

P value

Yes

(n = 4)

No

(n = 70)

P value

Sex (male,%)^c

19 (61.3%)

20 (46.5%)

0.523

13 (76.5%)

26 (45.6%)

0.100

3 (75.0%)

36 (51.4%)

0.840

Mean age (years)^a

45.68 ± 10.54

44.58 ± 13.01

0.665

45.00 ± 12.23

45.05 ± 12.01

0.923

39.00 ± 14.72

45.39 ± 11.83

0.775

Age of onset (years)^a

38.58 ± 11.34

38.94 ± 13.45

0.978

38.18 ± 12.31

38.97 ± 12.40

0.923

31.50 ± 13.63

39.21 ± 12.44

0.740

Disease duration (years)^b

7.10 ± 4.17

5.64 ± 7.37

0.047*

6.82 ± 5.09

6.08 ± 6.58

0.620

7.50 ± 8.96

6.18 ± 6.13

0.893

Educational year^b

11.03 ± 4.14

10.16 ± 4.79

0.665

10.06 ± 5.27

10.67 ± 4.31

0.926

9.50 ± 4.12

10.59 ± 4.56

0.775

BMI^b

20.85 ± 2.61

25.74 ± 28.03

0.665

20.32 ± 2.74

24.69 ± 24.37

0.442

21.65 ± 1.94

23.80 ± 22.07

0.791

Hyperreflexia^c

16 (51.6%)

17 (39.5%)

0.604

9 (52.9%)

24 (42.1%)

0.662

3 (75.0%)

30 (42.9%)

0.775

Vision loss^c

8 (25.8%)

16 (37.2%)

0.523

3 (17.6%)

21 (36.8%)

0.345

1 (25.0%)

23 (32.9%)

1.000

ICARS-I^d

14.74 ± 6.50

10.49 ± 6.34

0.048*

14.71 ± 5.58

11.54 ± 6.88

0.260

10.50 ± 5.92

12.37 ± 6.77

0.775

ICARS-II^d

18.97 ± 8.91

13.33 ± 8.34

0.048*

18.88 ± 7.88

14.74 ± 9.12

0.260

19.25 ± 9.46

15.49 ± 8.97

0.740

ICARS-III^d

2.19 ± 1.49

1.77 ± 1.56

0.665

2.94 ± 1.03

1.65 ± 1.54

0.020*

3.00 ± 1.15

1.89 ± 1.54

0.740

ICARS-IV^d

2.61 ± 1.45

1.98 ± 1.32

0.247

3.24 ± 1.35

1.95 ± 1.29

0.020*

3.25 ± 1.89

2.19 ± 1.37

0.740

Total ICARS score^d

38.52 ± 15.25

27.56 ± 15.64

0.047*

39.77 ± 13.00

29.88 ± 16.60

0.100

36.00 ± 17.57

31.93 ± 16.34

0.775

SARA score^d

13.39 ± 5.27

9.29 ± 5.48

0.047*

14.32 ± 4.54

10.02 ± 5.71

0.033*

12.50 ± 4.65

10.92 ± 5.80

0.775

MoCA score^e

23.03 ± 4.56

23.98 ± 4.78

0.257

22.29 ± 4.93

23.97 ± 4.58

0.371

21.25 ± 2.99

23.71 ± 4.74

0.740

HDRS-24 score^b

9.36 ± 9.86

8.40 ± 8.28

0.665

7.47 ± 3.92

9.13 ± 9.93

0.804

13.75 ± 7.14

8.51 ± 8.97

0.740

HARS score^b

7.10 ± 7.52

6.63 ± 6.76

0.751

6.41 ± 4.06

6.95 ± 7.74

0.620

7.00 ± 4.97

6.81 ± 7.17

0.775

ESS score^b

5.29 ± 4.97

5.49 ± 4.50

0.751

5.41 ± 4.05

5.40 ± 4.88

0.923

3.00 ± 2.94

5.54 ± 4.73

0.775

PSQI score^b

6.84 ± 4.58

7.51 ± 4.40

0.665

6.94 ± 4.72

7.32 ± 4.42

0.827

7.50 ± 2.52

7.21 ± 4.56

0.840

CAG repeat length^b

65.65 ± 11.37

66.37 ± 11.12

0.691

65.29 ± 12.99

66.30 ± 10.66

0.987

48.50 ± 19.09

67.07 ± 9.84

0.740