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Table 1 Comparison about the demographic and clinical features between NMOSD-NOSIS patients with different developments

From: Neuromyelitis optica spectrum disorders with non opticospinal manifestations as initial symptoms: a long-term observational study

 

Total n = 43

NMOSD-NOSIS developing ON/MY

n = 38

NMOSD-NOSIS restricted in non-ON/MY

n = 5

P value

Age of onset, y, median(IQR)

28.00(21.00–37.00)

28.00(20.75–35.50)

26.00(22.50–42.00)

0.652

Female, n(%)

38(88.37)

33(86.84)

5(100)

0.904

AQP4-IgG+, n(%)

36 (83.72 )

32 (84.21 )

4 (80.00)

0.811

ARR, median(IQR)

0.75(0.50–1.27)

0.75(0.50–1.25)

0.67(0.48–3.00)

0.657

Coexisting autoimmunity, n(%)

6 (13.95)

5 (13.16)

1 (20.00)

0.592

CSF leukocyte cell count, n/ul, median(IQR)

0.30(0–4.00)

3.00(0–4.00)

1.00(0–14.00)

0.983

CSF protein, mg/L, mean(SD)

0.26 ± 0.13

0.26 ± 0.14

0.26 ± 0.11

0.980

EDSS at onset, median(IQR)

0(0–2.00)

0(0–2.00)

2.00(1.00–2.00)

0.356

EDSS at follow-up, median(IQR)

2.50(2.00–3.00)

2.75(1.75–3.00)

2.00(1.00–3.75)

0.622

Follow-up, y, median(IQR)

5.00(3.00–8.00)

5.50(3.00–8.25)

3.00(1.00–5.00)

0.042

  1. NMOSD neuromyelitis optica spectrum disorders, NMOSD-NOSIS NMOSD with non-opticospinal manifestations as initial symptoms, NMOSD-OSIS NMOSD with opticospinal manifestations as initial symptoms, IQR Interquartile range, ON optic neurotis, MY myelitis, AQP4 anti-aquaporin-4, ARR annual relapse rate, CSF cerebral spinal fluid, EDSS expanded disability status scale