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Table 1 Baseline characteristics of AIS patients without HT and with HT

From: Hemostasis functions are associated with hemorrhagic transformation in non-atrial fibrillation patients: a case-control study

Variables

Total (n=570)

Non-HT (n=285)

HT (n=285)

P-value

Demographic characteristics

 Age (years)

68.9 ± 12.4

68.9 ± 12.3

68.9 ± 12.6

0.970

 Male, n (%)

388 (68.1%)

191 (67.0%)

197 (69.1%)

0.590

 Baseline SBP (mmHg)

153.3 ± 23.1

158.0 ± 23.0

148.6 ± 22.3

< 0.001

 Baseline DBP (mmHg)

82.3 ± 13.8

82.1 ± 13.3

82.5 ± 14.3

0.732

 NIHSS on admission, median (IQR)

5.0 (2.0–10.0)

3.0 (1.0–5.0)

9.0 (5.0–13.0)

< 0.001

 CTA, n (%)

64 (11.2%)

30 (10.5%)

34 (11.9%)

0.616

Vascular risk factors, n (%)

 Current smoking

210 (37.1%)

118 (41.5%)

92 (32.6%)

0.028

 Current drinking

228 (40.4%)

141 (49.8%)

87 (30.9%)

< 0.001

 Previous Stroke

72 (12.6%)

31 (10.9%)

41 (14.4%)

0.207

 Hypertension

376 (66.0%)

197 (69.1%)

179 (62.8%)

0.112

 Diabetes

149 (26.1%)

80 (28.1%)

69 (24.2%)

0.294

 CAD

47 (8.3%)

15 (5.3%)

32 (11.3%)

0.010

 Dyslipidemia

37 (6.5%)

17 (6.0%)

20 (7.0%)

0.610

 AF

137 (24.0%)

29 (10.2%)

108 (37.9%)

< 0.001

Hematological variables

 Leukocyte counts (×109/L)

7.7 ± 2.8

6.8 ± 1.9

8.5 ± 3.3

< 0.001

 Erythrocyte counts (×109/L)

4.4 ± 0.6

4.4 ± 0.6

4.4 ± 0.6

0.836

 PLT (× 109/L), median (IQR)

197.0 (162.0–235.0)

205.0 (175.0–238.5)

187.0 (148.5–231.0)

< 0.001

 MPV (fl)

11.0 ± 1.4

11.2 ± 1.2

10.8 ± 1.4

0.011

 PT (s)

13.7 ± 1.0

13.5 ± 1.0

13.9 ± 1.0

< 0.001

 INR

1.1 ± 0.1

1.0 ± 0.1

1.1 ± 0.1

< 0.001

 FIB (g/L)

3.8 ± 1.6

3.5 ± 1.0

4.1 ± 2.0

< 0.001

Stroke etiology, n (%)

   

< 0.001

 Atherosclerosis

405 (75.6%)

214 (84.9%)

191 (67.3%)

 

 Cardioembolism

109 (20.3%)

20 (7.9%)

89 (31.3%)

 

 Small vessel occlusion

4 (0.7%)

3 (1.2%)

1 (0.4%)

 

 Other causes

18 (3.3%)

15 (6.0%)

3 (1.1%)

 

Treatment, n (%)

 Anticoagulant therapy

114 (20%)

28 (9.8%)

86 (30.2%)

< 0.001

 Antiplatelet therapy

419 (73.5%)

256 (89.8%)

163 (57.2%)

< 0.001

 Aspirin

201 (35.3%)

120 (42.1%)

81 (28.4%)

0.001

 Clopidogrel

122 (21.4%)

78 (27.4%)

44 (15.4%)

< 0.001

 Double antiplatelet therapy

96 (16.8%)

58 (20.4%)

38 (13.3%)

0.025

  1. Abbreviations: HT, hemorrhagic transformation; SBP, systolic blood pressure; DBP, diastolic blood pressure; NIHSS, National Institute of Health Stroke Scale; CTA, computered tomograhy angiography; CAD, coronary artery disease; AF, atrial fibrillation; PLT, platelet counts; MPV, mean platelet volume; PT, prothrombin time; INR, International Normalized Ratio; FIB, fibrinogen