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Table 2 Relationship between PDQ-39 scores and presence/absence of “OFF” episodes (N = 722)

From: Real-world assessment of the impact of “OFF” episodes on health-related quality of life among patients with Parkinson’s disease in the United States

PDQ-39 dimensions Coefficient (95% CI)a P value
Mobility + 7.9 (4.4, 11.4) <  0.001
Activities of daily living + 6.7 (3.2, 10.1) <  0.001
Emotional well-being + 4.5 (0.7, 8.3) 0.019
Stigma + 3.0 (−0.1, 6.1) 0.057
Social support + 2.3 (−0.7, 5.3) 0.134
Cognitions + 6.5 (3.5, 9.4) <  0.001
Communication + 9.0 (6.0, 11.9) <  0.001
Bodily discomfort + 1.7 (−3.0, 6.5) 0.470
Summary index + 5.2 (2.8, 7.6) <  0.001
  1. aEffect coefficient for difference between patients with/without “OFF” episodes from linear regression; + indicates a higher score on the PDQ-39 dimension or summary index, indicating poorer health-related quality of life, in patients with “OFF” episodes compared with patients without “OFF” episodes
  2. CI confidence interval; PDQ-39 39-item Parkinson’s Disease Questionnaire