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Table 3 Relationship between PDQ-39 items and presence/absence of “OFF” episodes (N = 722)

From: Real-world assessment of the impact of “OFF” episodes on health-related quality of life among patients with Parkinson’s disease in the United States

PDQ-39 items

Odds ratio

(95% CI)a

P value

Mobility

 Had difficulty doing the leisure activities which you would like to do

2.2 (1.5, 3.0)

<  0.001

 Had difficulty looking after your home

1.9 (1.4, 2.6)

<  0.001

 Had difficulty carrying bags of shopping

1.7 (1.2, 2.3)

0.002

 Had problems walking half a mile

1.4 (1.0, 2.0)

0.028

 Had problems walking 100 yards

2.0 (1.5, 2.7)

<  0.001

 Had problems getting around the house as easily as you would like

2.2 (1.6, 3.0)

<  0.001

 Had difficulty getting around in public

1.8 (1.3, 2.6)

<  0.001

 Needed someone else to accompany you when you went out

1.9 (1.3, 2.6)

0.001

 Felt frightened or worried about falling over in public

1.5 (1.0, 2.1)

0.040

 Been confined to the house more than you would like

2.5 (1.9, 3.3)

<  0.001

Activities of daily living

 Had difficulty washing yourself

1.8 (1.3, 2.4)

<  0.001

 Had difficulty dressing yourself

1.8 (1.3, 2.4)

<  0.001

 Had problems doing up buttons or shoelaces

1.7 (1.3, 2.3)

0.001

 Had problems writing clearly

2.2 (1.6, 2.9)

<  0.001

 Had problems cutting up your food

1.4 (1.0, 2.0)

0.027

 Had difficulty holding a drink without spilling it

1.3 (0.9, 1.8)

0.108

Emotional well-being

 Felt depressed

1.3 (0.9, 1.9)

0.176

 Felt isolated and lonely

1.7 (1.2, 2.3)

0.003

 Felt weepy or tearful

1.5 (1.0, 2.1)

0.055

 Felt angry or bitter

1.5 (1.1, 2.1)

0.014

 Felt anxious

1.5 (1.0, 2.2)

0.026

 Felt worried about your future

1.2 (0.8, 1.8)

0.391

Stigma

 Felt you had to conceal your Parkinson’s from people

1.3 (0.9, 1.8)

0.127

 Avoided situations which involve eating or drinking in public

1.5 (1.1, 2.1)

0.010

 Felt embarrassed in public due to having Parkinson’s disease

1.3 (0.9, 1.8)

0.100

 Felt worried by other people’s reaction to you

1.2 (0.9, 1.7)

0.246

Social support

 Had problems with your close personal relationships

1.5 (1.0, 2.1)

0.048

 Lacked support in the ways you need from your spouse or partner

1.2 (0.8, 2.0)

0.399

 Lacked support in the ways you need from your family or close friends

1.3 (0.8, 2.0)

0.295

Cognitions

 Unexpectedly fallen asleep during the day

1.8 (1.3, 2.5)

<  0.001

 Had problems with your concentration

2.1 (1.5, 2.9)

<  0.001

 Felt your memory was bad

1.3 (1.0, 1.9)

0.090

 Had distressing dreams or hallucinations

1.8 (1.3, 2.5)

<  0.001

Communication

 Had difficulty with your speech

3.4 (2.3, 4.9)

<  0.001

 Felt unable to communicate with people properly

3.2 (2.3, 4.5)

<  0.001

 Felt ignored by people

2.0 (1.4, 2.9)

<  0.001

Bodily discomfort

 Had painful muscle cramps or spasms

1.2 (0.8, 1.9)

0.328

 Had aches and pains in your joints or body

1.1 (0.7, 1.7)

0.801

 Felt unpleasantly hot or cold

1.3 (0.9, 1.9)

0.189

  1. aOdds ratio for difference between patients with/without “OFF” episodes from ordered logistic regression; an odds ratio > 1 indicates higher likelihood of problems in a PDQ-39 item, indicating poorer health-related quality of life, in patients with “OFF” episodes compared with patients without “OFF” episodes
  2. CI confidence interval; PDQ-39 39-item Parkinson’s Disease Questionnaire