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Table 4 Relationship between EQ-5D scores and presence/absence of “OFF” episodes (N = 722)

From: Real-world assessment of the impact of “OFF” episodes on health-related quality of life among patients with Parkinson’s disease in the United States

EQ-5D dimensions Odds ratio (95% CI)a P value
Mobility 2.1 (1.3, 3.5) 0.002
Self-care 1.4 (0.9, 2.1) 0.112
Usual activities 2.6 (1.8, 3.7) <  0.001
Pain/discomfort 1.2 (0.8, 1.8) 0.467
Anxiety/depression 1.6 (1.1, 2.2) <  0.001
  Coefficient (95% CI)b P value
Health utility index −0.04 (−0.07, −0.02) <  0.001
VAS −6.75 (−9.49, −4.00) <  0.001
  1. aOdds ratio for difference between patients with/without “OFF” episodes from ordered logistic regression on the categorical EQ-5D responses (indicating no problem/some problem/extreme problem). bEffect coefficient for difference between patients with/without “OFF” episodes from linear regression on EQ-5D utility index and VAS; − indicates a lower score on the EQ-5D utility index or VAS, indicating poorer health status, in patients with “OFF” episodes compared with patients without “OFF” episodes
  2. CI confidence interval; EQ-5D EuroQol 5-Dimension; VAS visual analog scale