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Table 4 Relationship between EQ-5D scores and presence/absence of “OFF” episodes (N = 722)

From: Real-world assessment of the impact of “OFF” episodes on health-related quality of life among patients with Parkinson’s disease in the United States

EQ-5D dimensions

Odds ratio (95% CI)a

P value

Mobility

2.1 (1.3, 3.5)

0.002

Self-care

1.4 (0.9, 2.1)

0.112

Usual activities

2.6 (1.8, 3.7)

<  0.001

Pain/discomfort

1.2 (0.8, 1.8)

0.467

Anxiety/depression

1.6 (1.1, 2.2)

<  0.001

 

Coefficient (95% CI)b

P value

Health utility index

−0.04 (−0.07, −0.02)

<  0.001

VAS

−6.75 (−9.49, −4.00)

<  0.001

  1. aOdds ratio for difference between patients with/without “OFF” episodes from ordered logistic regression on the categorical EQ-5D responses (indicating no problem/some problem/extreme problem). bEffect coefficient for difference between patients with/without “OFF” episodes from linear regression on EQ-5D utility index and VAS; − indicates a lower score on the EQ-5D utility index or VAS, indicating poorer health status, in patients with “OFF” episodes compared with patients without “OFF” episodes
  2. CI confidence interval; EQ-5D EuroQol 5-Dimension; VAS visual analog scale