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Table 4 Outcome measures

From: Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry

 

All patients acute ischemic strokea

(n = 156)

Cryptogenic stroke

(n = 55)

Cardioembolic stroke

(n = 35)

Large vessel stroke

(n = 15)

Small vessel stroke

(n = 4)

Other

(n = 11)

p-valueb

p-valuec

Hemorrhagic transformation of infarction, no. (%)

17/98 (17.4)

6/42 (14.3)

3/26 (11.5)

0/8 (0)

0/4 (0)

4/7 (57.1)

0.05

0.55

Grade of hemorrhage

> 0.9

0.82

 HI-1

7/17 (41.2)

3/6 (50.0)

1/3 (33.3)

n/a

n/a

2/4 (50.0)

  

 HI-2

2/17 (11.8)

1/6 (16.7)

0/3 (0)

n/a

n/a

1/4 (25.0)

  

 PH-1

4/17 (23.5)

1/6 (16.7)

1/3 (33.3)

n/a

n/a

1/4 (25.0)

  

 PH-2

4/17 (23.5)

1/6 (16.7)

1/3 (33.3)

n/a

n/a

0/4 (0)

  

 Symptomatic ICHd, no. (%)

1/14 (7.1)

1/4 (25.0)

0/3 (0)

n/a

n/a

0/4 (0)

> 0.9

> 0.9

 Transfer to ICU, no. (%)

69/145 (47.6)

26/52 (50.0)

11/33 (33.3)

10/15 (66.7)

0/4 (0)

10/11 (90.9)

< 0.01

0.36

 Intubation, no. (%)

51/139 (36.7)

17/47 (36.2)

7/32 (21.9)

4/15 (26.7)

0/4 (0)

7/11 (63.6)

0.08

0.56

Discharge disposition, no. (%)

0.57

0.55

 Home

34/136 (25.0)

11/50 (22.0)

9/29 (31.0)

4/14 (28.6)

2/4 (50.0)

5/11 (45.5)

  

 Acute inpatient rehabilitation

18/136 (13.2)

8/50 (16.0)

3/29 (10.3)

1/14 (7.1)

1/4 (25.0)

2/11 (18.2)

  

 Skilled nursing facility or subacute rehabilitation

20/136 (14.7)

5/50 (10.0)

6/29 (20.7)

4/14 (28.6)

0/4 (0)

2/11 (18.2)

  

 Long-term acute care

5/136 (3.7)

2/50 (4.0)

1/29 (3.5)

2/14 (14.3)

0/4 (0)

0/11 (0)

  

 Other acute care facility

7/136 (5.2)

3/50 (6.0)

3/29 (10.3)

0/14 (0)

0/4 (0)

0/11 (0)

  

 Hospice

2/136 (1.5)

1/50 (2.0)

0/29 (0)

0/14 (0)

0/4 (0)

1/11 (9.1)

  

 Expired during hospitalization

53/139 (38.1)

20/50 (40.0)

7/29 (24.1)

3/14 (21.4)

1/4 (25.0)

1/11 (9.1)

  

 Modified Rankin Scale at discharge, median (IQR)

4 (2–6)

(n = 139)

5 (3–6)

(n = 51)

4 (2–5)

(n = 32)

4 (2–5)

(n = 14)

1 (0–4)

(n = 4)

3 (2–4)

(n = 10)

0.20

0.07

 Discharge mRS 0–2, no. (%)

35/139 (25.2)

11/51 (21.6)

11/32 (34.4)

4/14 (28.6)

3/4 (75.0)

3/10 (30.0)

0.21

0.14

In-hospital mortality, no. (%)

53/139 (38.1)

20/50 (40.0)

7/29 (24.1)

3/14 (21.4)

1/4 (25.0)

1/11 (9.1)

0.18

0.05

  1. a Acute ischemic stroke includes suspected or radiographically-confirmed cases, and in patients with multiple possible stroke mechanisms (n = 9). Patients with multiple stroke mechanisms were not included in the subsequent columns in order to minimize heterogeneity
  2. b P-values indicate categorical comparisons between all stroke subtypes
  3. c P-values indicate comparisons between cryptogenic and non-cryptogenic stroke subtypes (including strokes due to multiple possible etiologies)
  4. d Symptomatic ICH defined as a PH-2 grade hematoma with worsening of the NIHSS by 4 or more points