Table 1 Detailed report of brain metastasis from nasopharyngeal carcinoma
Author/ year | Sex/ age | Major treatment for NPC | Site in the brain | Systemic metastasis | Pathology of brain metastatic focus | EBV detection | Time interval between onset/ diagnosis of NPC and identification of brain metastasis | Perifocal edema of metastases | Morphology of brain metastases | Enhancement change | Treatment for brain metastases |
|---|---|---|---|---|---|---|---|---|---|---|---|
Liaw et al./1994 [5] | Male/69 | nd | Bilateral occipital | + bone | Non-keratinizing squamous cell carcinoma | nd | 2 years | + | Cystic and Non cystic | + | Chemoradiotherapy. |
Ngan et al./2002 [8] | Male/33 | Chemoradiotherapy | Left occipital | + lung | Undifferentiated carcinoma | + | 51 months | + | Cystic | nd | Surgery |
Özyar et al./2004 [9] | Male/41 | Radiotherapy | Right temporal lobe | - | Undifferentiated carcinoma | - | 45 months | + | Non cystic | Homogenously enhancing | Whole brain radiotherapy |
Kaidar-Person O et al/2012 [10] | Male/56 | Chemoradiotherapy | Occipital | + lung | Undifferentiated carcinoma | + | 3 months | nd | nd | nd | Radiotherapy |
Kuo CL et al./ 2014 [11] | female/37 | Chemoradiotherapy | Dura and frontotemporal lobe | - | Differentiated non-keratinizing carcinoma | + | 7 months | + | Non cystic | Heterogeneously enhancing | Chemoradiotherapy and surgery |
Su Z et al/2019 [12] | Male/43 | Chemoradiotherapy | Brain and frontal bone | - | Undifferentiated non-keratinizing carcinoma | - | 3.5 years | Not obvious | Non cystic | + | Chemoradiotherapy |