Table 3 Distribution of CAG repeat lengths in pathological and non-pathological ranges by group and gender
HD group | Carrier group | Control group (Alleles [individuals]) | All pathological alleles | All non-pathological alleles | |
|---|---|---|---|---|---|
CAG repeats of pathological range (≥ 36) | |||||
N (male/female) | 86 (42/44) | 34 (15/19) | – | 120 (57/63) | – |
Median (male/female) | 45 (45/43.5) | 41 (42/41) | – | 43 (42/44) | – |
Range (male/female) | 36–70 (38–59/36–70) | 36–52 (36–52/36–49) | – | 36–70 (36–59/36/70) | – |
CAG repeats of decreased penetrance (36–39) | |||||
N (male/female) | 12 (3/9) | 9 (2/7) | – | 21 (5/16) | – |
Percent of respective group members | 13.3% | 26.5% | – | 17.5% | – |
CAG repeats of non-pathological range (< 36) | |||||
N (male/female)a | 75 (34/41) | 30 (13/17) | 124 (64/60) | – | 229 (111/118) |
Median (male/female) | 18 (18/19) | 19 (19/19) | [62 (32/30)] | – | 19 (19/19) |
Range (male/female) | 9–28 (10–28/9–27) | 14–24 (16–23/14–24) | 20 (20/19) 10–35 (10–33/11/35) | – | 9–35 (10–33/9–35) |
CAG repeats of intermediate range (27–35) | |||||
N (male, female) | 3 (2/1) | 0 | 13 (7/6) | – | 16 (9/7) |
Percent of respective group members | 4% | 0 | 10.5% [21%] | – | 7% |