Skip to main content

Table 1 Characteristics of studies comparing AF IVT with non-AF IVT

From: Efficacy and safety of thrombolysis for acute ischemic stroke with atrial fibrillation: a meta-analysis

Study Study design Comparison No. of patients Mean age, y Men (%) Treatment Hypertension (%) Diabetes mellitus (%) Dyslipidemia (%) Baseline NIHSS Onset to needle (min) Mortality, % SICH, %
Bluhmki 2009 [5] prospective RCT AF/non-AF 53/365 NR NR rtPA
3–4.5 h
NR NR NR NR NR 22.6/5.5, 90d 17.0/6.6
Kimura 2009 [6] prospective AF/non-AF 44/41 77.2/69.4 61.4/70.7 rtPA
< 3 h
63.6/51.2 18.2/22.0 13.6/31.7 17.3/12.3 148.3/147.6 18.2/7.3, 90d NR
Awadh 2010 [24] retrospective AF/non-AF 74/154 76/66.4 40/59 rtPA
< 4.5 h
70/64 16.2/7.8 19/22 14/ 14.5 162.7/173.3 NR 4.0/4.5
Sanak 2010 [16] retrospective AF/non-AF 66/91 68.1/66.5 57.6/65.9 rtPA
< 3 h
NR NR NR 13.0/10.0 146.3/145.5 18.2/3.3, 7d 4.5/0
Zhang 2010 [7] retrospective AF/non-AF 22/31 68.3/60.7 40.9/74.2 rtPA
< 4.5 h
72.7/38.5 13.6/6.5 NR 12.0/9.1 203.7/196.7 18.2/9.7, 90d 18.2/6.5
Seet 2011 [8] retrospective AF/non-AF 76/138 78.9 /71.5 42.1/53.6 rtPA
< 3 h
78.9/75.4 10.5/14.5 50.0/51.4 13 /12 138.3/143.5 22.4/15.2, 90d 13.2/5.1
Frank 2012 [9] retrospective AF/non-AF 639/2388 74.2 /65.7 47.3/58.2 rtPA
< 3 h
71.1/61.6 NR NR 15 /13 NR 21.8/13.6, 90d 2.7/1.7
Padjen 2013 [10] prospective AF/non-AF 155/579 76 /64 41.9/55.6 rtPA 80.0/62.3 20.0/15.7 45.2/45.9 14/10 148/153 21.9/9.0, 90d 5.8/5.5
Saposnik 2013 [11] prospective AF/non-AF 316/1373 NR NR rtPA NR NR NR NR NR 26.3/14.2, 30d 9.2/6.4
Sung 2013 [14] retrospective AF/non-AF 72/71 68.3/64.6 58.3/64.8 rtPA
< 3 h
79.2/77.5 27.8/39.4 51.4/64.8 17.7/14.4 113/119 6.9/12.7, 90d 8.3/9.8
Al-Khaled 2014 [17] prospective AF/non-AF 387/620 NR NR rtPA
< 4.5 h
NR NR NR NR up to 4.5 h 10.8/6.6, in-hospital 7.5/4.7
Saarinen 2014 [18] retrospective AF/non-AF 92/179 77 /69 46/55 NR
< 3 h
74/63 32/17 NR NR NR 20/6, 90d NR
Tu 2015 [19] prospective AF/non-AF 28/111 76.5/73 61/52 rtPA
3-6 h
64/64 21/26 29/32 16/11 NR 36/16, 90d 7.1/4.5
Zhao 2017 [12] retrospective AF/non-AF 30/93 69.8/63.5 46.7/67.7 rtPA
< 4.5 h
73.3/65.6 30.0/18.3 30.0/39.8 12/8 227/174 13.3/2.2 13.3/5.4
Mehrpour 2019 [13] retrospective AF/non-AF 24/94 NR NR rtPA
< 4.5 h
NR NR NR NR NR NR NR
Yang 2019 [15] retrospective AF/non-AF 47/56 71.2 /60.4 34.0/80.4 rtPA
3-9 h
74.5/64.3 19.1/23.2 NR 11.5 /9.3 322.9/370.4 10.6/7.1, 90d 2.1/3.6