Fig. 3

Correlation analysis for deep regional CBF, echocardiographic parameters, neuroimaging markers and multivariate regression analysis for factors associated with CSVD burden^high a Spearman correlation matrix of CSVD radiological markers, deep regional CBF and echocardiographic parameters (number shown in the matrix is r coefficient with statistical significance, * for P < 0.05 and ** for P < 0.01) b Forest plot of binary logistic regression analysis for CSVD burden^high (covariables including age, body mass index, hypertension, symptomatic stroke, diabetes, fasting plasma glucose and eGFR) c ROC curve for predicting CSVD burden^high Black dashed line denotes ROC curve analysed with clinical risk factors including age, hypertension, symptomatic stroke and eGFR; red solid line denotes ROC curve analysed with clinical risk, mean deep regional CBF and echocardiographic parameters including ARD, RVD, IVS, LVEDD, LVPW, RAD, PAD, LVEF, FS and E/A ratio