Fig. 2

MRI scans of a 33 year old patient with IDH-wildtype glioblastoma. First (a) and second (b) MRI after resection and radiation therapy of recurrent glioblastoma showed not signs of tumor progression. Dexamethasone was started because of clinical deterioration before the third control (c) which showed a substantial increase in contrast enhancement and edema which were interpreted as late radiation necrosis. Bevacizumab 7.5 mg/kg was administered as a single-shot. d First scan 1.5 months later displayed a marked reduction of the edema while there was only a minor reduction of contrast enhancement. Diagnosis was changed from radiation necrosis to recurrent tumor