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Table 3 Univariate and multivariate analyses of risk factors for acute cerebral infarction

From: Clinical impact of estradiol/testosterone ratio in patients with acute ischemic stroke

 

Univariate analysis

Multivariate analysis

OR

95% CI

P-value

OR

95% CI

P-value

Systolic blood pressure

1.024

1.014-1.035

<0.001

1.016

1.003-1.029

0.013

Diastolic blood pressure

1.031

1.015-1.046

<0.001

1.015

0.998-1.033

0.085

Body mass index

0.969

0.900-1.044

0.412

   

Hypertension

1.809

1.140-2.868

0.012

1.750

1.026-2.984

0.040

Diabetes mellitus

1.614

0.931-2.798

0.088

   

Smoking, current

1.596

0.952-2.678

0.076

   

Alcohol, current

1.268

0.790-2.036

0.325

   

Cardiovascular diseasea

1.965

1.057-3.654

0.033

1.374

0.660-2.863

0.396

Hyperlipidemia

1.509

0.940-2.421

0.089

   

Atrial fibrillation

2.136

1.067-4.276

0.032

1.998

0.923-4.326

0.079

CKD

2.319

1.227-4.382

0.010

1.709

0.648-4.511

0.279

Total cholesterol

1.305

1.053-1.618

0.015

1.144

0.883-1.480

0.308

Triglyceride

1.288

1.018-1.631

0.035

1.313

0.997-1.728

0.053

HDL-cholesterol

0.510

0.237-1.098

0.085

   

LDL-cholesterol

1.248

0.980-1.589

0.072

   

HbA1c

1.164

0.984-1.377

0.077

   

eGFR

0.977

0.962-0.993

0.006

0.989

0.965-1.014

0.397

E2 (estradiol)

1.004

0.999-1.008

0.110

   

Total testosterone

0.976

0.950-1.002

0.075

   

Free testosterone

0.791

0.099-6.339

0.825

   

Progesterone

0.746

0.526-1.057

0.099

   

17-OH progesterone

0.986

0.878-1.107

0.808

   

E/T ratio

 1st tertile

Reference

 

Reference

 

 2nd tertile

2.000

1.128-3.547

0.018

1.813

0.955-3.442

0.069

 3rd tertile

3.500

1.950-6.283

<0.001

3.084

1.616-5.886

0.001

  1. OR odds ratio, CI confidence interval, CKD chronic kidney disease, HDL high-density lipoprotein, LDL low-density lipoprotein, eGFR estimated glomerular filtration rate, E/T ratio estradiol-to-testosterone ratio
  2. aCardiovascular disease includes coronary heart disease, heart failure, or peripheral arterial disease