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Table 2 Genotype and allele frequencies of three SNPs between case and control group

From: Single nucleotide polymorphisms in the ANGPTL4 gene and the SNP-SNP interactions on the risk of atherosclerotic Ischaemic stroke

SNP

Genotypes and alleles

Frequencies N (%)

OR (95% CI)a

P-value

HWE test for case

HWE test for controls

Cases

n = 360

Control

n = 342

rs11672433

 Genotype

CC

348 (96.7)

278 (81.3)

1.00

 

0.000

0.054

 

CT

6 (1.7)

57 (16.7)

0.15 (0.06–0.37)

0.000

  
 

TT

6 (1.7)

7 (2.0)

0.09 (0.02–0.52)

0.007

  
 

CT + TT

12 (3.3)

64 (18.8)

0.05 (0.02–0.11)

0.000

  

 Allele

C

702 (97.5)

613 (89.6)

0.22 (0.13–0.38)

0.000b

  
 

T

18 (2.5)

71 (10.4)

  

rs4076317

 Genotype

CC

179 (49.7)

154 (45.0)

1.00

 

0.633

0.402

 

CG

147 (40.8)

156 (45.6)

0.84 (0.58–1.20)

0.330

  
 

GG

34 (9.4)

32 (9.4)

0.87 (0.47–1.61)

0.662

  
 

CG + GG

181 (50.3)

188 (55.0)

0.83 (0.58–1.19)

0.317

  

 Allele

C

505 (70.1)

464 (67.8)

0.90 (0.72–1.13)

0.351 b

  
 

G

215 (29.9)

220 (32.2)

  

rs1044250

 Genotype

CC

315 (87.5)

292 (85.4)

1.00

 

0.001

0.165

 

CT

39 (10.8)

46 (13.4)

1.07 (0.60–1.90)

0.814

  
 

TT

6 (1.7)

4 (1.2)

2.82 (0.41–4.92)

0.291

  
 

CT + TT

45 (12.5)

50 (14.6)

1.01 (0.62–1.66)

0.758

  

 Allele

C

669 (92.9)

630 (92.1)

0.89 (0.60–1.32)

0.563 b

  
 

T

51 (7.1)

54 (7.9)

  
  1. aAdjusted for gender, age, smoking and alcohol status, hypertension, diabetes mellitus, TG,TC, HDL-C, LDL-C, Uric acid
  2. b Chi-square test for the allele frequencies between the cases and controls