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Table 1 Comparisons of demographic factors, clinical parameters, anti-AQP4 antibody status and MRI features between the good and poor three-month EDSS outcome groups

From: Correlations among disability, anti-AQP4 antibody status and prognosis in the spinal cord involved patients with NMOSD

Group Good outcome (EDSS < 4, N = 9) Poor outcome (EDSS > 4, N = 13) p-values
Onset age (years) 43.1 ± 17.6 42.6 ± 9.1 0.74
Onset to nadir time (days) 7.9 ± 6.5 8.7 ± 6.1 0.71
Initial symptoms    0.68
 Optic neuritis 2 2  
 Spinal cord lesions 7 11  
All-limb muscle power (MRC score) 17.4 ± 3.7 14.7 ± 2.5 0.01
Upper-limb muscle power (MRC score) 4.8 ± 0.4 4.5 ± 0.6 0.10
Lower-limb muscle power (MRC score) 3.9 ± 1.6 2.9 ± 1.1 0.01
EDSS scores at the nadir 4.3 ± 2.5 7.9 ± 1.4 <  0.01
Three-month all-limb muscle power (MRC scores) 19.1 ± 0.9 16.2 ± 2.6 < 0.01
Three-month upper-limb muscle power (MRC scores) 4.9 ± 0.2 4.5 ± 0.5 0.02
Three-month lower-limb muscle power (MRC scores) 4.6 ± 0.4 3.6 ± 1.2 <  0.01
Three-month EDSS scores 2.5 ± 0.7 5.8 ± 1.3 < 0.01
Sphincter incontinence (Y:N) 2:7 6:7 0.25
Follow-up period (Months) 108.1 ± 25.5 74.4 ± 58.6 0.12
Relapse episodes 4.6 ± 2.6 5.7 ± 5.9 0.97
Anti-AQP4 antibody level (Unit/mL) 67.4 ± 81.4 125.1 ± 98.2 0.27
Anti-AQP4 antibody status (Negative: Positive) 2:7 1:12 0.33
MRI features
 The length of spinal cord lesions (vertebral body span) 4.9 ± 1.7 4.9 ± 1.4 0.84
 Axial anterior pattern (Y:N) 1:8 2:11 0.77
 Axial central pattern (Y:N) 5:4 8:5 0.78
 Axial lateral pattern (Y:N) 5:4 6:7 0.66
 Axial posterior pattern (Y:N) 3:6 7:6 0.34
 Bright spotty lesions (Y:N) 5:4 9:4 0.51
 Gd enhancement (Y:N) 7:2 7:6 0.64
  1. EDSS Expanded Disability Status Scale, AQP4 aquaporin-4, MRC Medical Research Council, Gd Gadolinium, Y yes, N No