From: Prediction of survival in amyotrophic lateral sclerosis: a nationwide, Danish cohort study
All | Group 1 (slow progression) | Group 2 (fast progression) | p-value | |
---|---|---|---|---|
ΔFS’ (mean ± SD) | 0.9 (±0.9) | 0.4 (±0.2) | 1.4 (±1.0) | 1.4e-8 |
No. of patients | 90 | 45 | 45 | – |
Age at onset, yrs. (mean ± SD) | 62.9 (±11.5) | 62.3 (±12.6) | 63.4 (±10.3) | 0.64 |
Sex, F/M | 39/51 | 23/22 | 16/29 | 0.62 |
Bulbar onset | 26 | 16 | 10 | 0.40 |
Spinal onset | 57 | 26 | 31 | 0.64 |
Truncal onset | 1 | 1 | 0 | – |
Mixed spinal and bulbar onsets | 6 | 3 | 3 | – |
Onset to diagnosis, mo (mean ± SD) | 16.6 (±11.5) | 22.3 (±12.8) | 10.8 (±5.8) | 9.0e-5 |
Onset to test date, mo (mean ± SD) | 22.4 (±20.7) | 31.2 (±24.8) | 13.7 (±9.5) | 4.9e-5 |
ALSFRS-R at test date (mean ± SD) | 34.5 (±9.3) | 36.5 (±9.1) | 32.6 (±9.3) | 0.043 |