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Table 3 The median survival time from onset of symptoms until the primary end point is calculated in association with ΔFS’ divided into two groups by the 50% quantile, ΔFS’ divided arbitrarily into three groups, and with age divided by the 50% quantile

From: Prediction of survival in amyotrophic lateral sclerosis: a nationwide, Danish cohort study

  Kaplan-Meier survival analysis Cox proportional hazards
No. of pts. MST p (log-rank) Hazard Ratio CI p
ΔFS’
 Group 1, < 0.68 (Slow) 45 46.5 1
 Group 2, ≥0.68 (Fast) 45 25.2 1.3e-7 3.66 2.17–6.18 1.1e-6
ΔFS’
  < 0.5 (Slow) 29 55.5 1
 0.5–1.0 (Medium) 34 31.7 5.5e-5 3.12 1.66–5.85 3.9e-4
  > 1.0 (Fast) 27 19.8 0.0032 7.50 3.71–15.17 2.1e-8
Age (yrs)
  < 65.2 45 40.4 1
  ≥ 65.2 45 25.9 8.0e-4 2.18 1.34–3.54 0.0017
  1. CI Confidence interval, ΔFS’ ALSFRS-R progression rate, MST Median survival time (from onset of symptoms until primary endpoint in months), p: p-value, pts. Patients, yrs. Years