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Table 4 Association of leakage rate, area under the leakage curve, and fractional blood plasma volume with MoCA

From: Increase of blood-brain barrier leakage is related to cognitive decline in vascular mild cognitive impairment

 

Spearman correlation

Univariable a

Multivariable b

r

P

β

P

β

P

NAWM

 Ktrans (10−4 min−1)

−0.384

0.008

−6.260

0.026

−4.718

0.080

 AUC

−0.316

0.030

−0.719

0.063

−0.246

0.590

 Vp (10–2)

0.425

0.003

0.463

0.009

0.439

0.011

WMH

 Ktrans (10−4 min−1)

−0.540

<0.001

−6.205

<0.001

−4.363

0.010

 AUC

−0.551

<0.001

−0.780

0.002

−0.511

0.063

 Vp (10–2)

0.122

0.412

0.048

0.631

−0.003

0.977

CGM

 Ktrans (10−4 min−1)

−0.425

0.003

−1.214

0.061

−0.571

0.358

 AUC

−0.264

0.073

−0.140

0.115

0.011

0.913

 Vp (10–2)

0.443

0.002

0.129

0.003

0.132

0.004

DGM

 Ktrans (10−4 min−1)

−0.437

0.002

−2.322

0.011

−1.346

0.132

 AUC

−0.288

0.049

−0.317

0.054

0.006

0.971

 Vp (10–2)

0.267

0.070

0.085

0.237

0.056

0.449

  1. Abbreviations: MoCA Montreal Cognitive Assessment, NAWM normal-appearing white matter, WMH white matter hyperintensities, CGM cortex grey matter, DGM deep grey matter, Ktrans leakage rate, AUC area under the leakage curve, Vp fractional blood plasma volume
  2. aUnivariable linear regression analysis with MoCA as dependent variable, and Ktrans, AUC, and Vp respectively, as independent variable
  3. bMultivariable linear regression analysis with MoCA as dependent variable, and Ktrans, AUC, Vp, age, sex, vascular risk factors, and education years as independent variables
  4. β, Unstandardized regression coefficient