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Table 4 Association of leakage rate, area under the leakage curve, and fractional blood plasma volume with MoCA

From: Increase of blood-brain barrier leakage is related to cognitive decline in vascular mild cognitive impairment

  Spearman correlation Univariable a Multivariable b
r P β P β P
NAWM
 Ktrans (10−4 min−1) −0.384 0.008 −6.260 0.026 −4.718 0.080
 AUC −0.316 0.030 −0.719 0.063 −0.246 0.590
 Vp (10–2) 0.425 0.003 0.463 0.009 0.439 0.011
WMH
 Ktrans (10−4 min−1) −0.540 <0.001 −6.205 <0.001 −4.363 0.010
 AUC −0.551 <0.001 −0.780 0.002 −0.511 0.063
 Vp (10–2) 0.122 0.412 0.048 0.631 −0.003 0.977
CGM
 Ktrans (10−4 min−1) −0.425 0.003 −1.214 0.061 −0.571 0.358
 AUC −0.264 0.073 −0.140 0.115 0.011 0.913
 Vp (10–2) 0.443 0.002 0.129 0.003 0.132 0.004
DGM
 Ktrans (10−4 min−1) −0.437 0.002 −2.322 0.011 −1.346 0.132
 AUC −0.288 0.049 −0.317 0.054 0.006 0.971
 Vp (10–2) 0.267 0.070 0.085 0.237 0.056 0.449
  1. Abbreviations: MoCA Montreal Cognitive Assessment, NAWM normal-appearing white matter, WMH white matter hyperintensities, CGM cortex grey matter, DGM deep grey matter, Ktrans leakage rate, AUC area under the leakage curve, Vp fractional blood plasma volume
  2. aUnivariable linear regression analysis with MoCA as dependent variable, and Ktrans, AUC, and Vp respectively, as independent variable
  3. bMultivariable linear regression analysis with MoCA as dependent variable, and Ktrans, AUC, Vp, age, sex, vascular risk factors, and education years as independent variables
  4. β, Unstandardized regression coefficient