Table 1 Baseline disease characteristics by previous preventive medication treatment failurea
Preventive medication | Number of monthly migraine headache days, mean (SD) | MSQ-RFR score, mean (SD) | Number of prior migraine preventive medications failed in lifetime, mean (SD) | Number of patients who did not benefit from treatment, n (%) | ||||
|---|---|---|---|---|---|---|---|---|
PBO | GMB 120 mg | PBO | GMB 120 mg | PBO | GMB 120 mg | due to inadequate efficacy b | due to safety/tolerability | |
Topiramate | 13.1 (5.8) | 13.5 (6.1) | 42.4 (16.7) | 43.9 (15.6) | 3.6 (1.8) | 3.7 (1.8) | 270 (58.4) | 95 (20.6) |
Amitriptyline | 13.4 (5.8) | 14.3 (6.2) | 43.8 (18.8) | 45.5 (17.5) | 3.7 (1.9) | 3.9 (1.8) | 215 (46.5) | 69 (14.9) |
Propranolol | 14.4 (6.3) | 14.4 (5.9) | 44.3 (19.0) | 44.0 (17.8) | 4.3 (2.0) | 4.1 (2.0) | 135 (29.2) | 26 (5.6) |
Valproate or divalproex | 12.6 (5.8) | 13.2 (5.6) | 46.7 (19.0) | 49.1 (16.9) | 3.8 (1.8) | 3.8 (1.9) | 123 (26.6) | 39 (8.4) |
Onabotulinum toxin A | 15.9 (5.4) | 16.5 (5.6) | 40.3 (19.2) | 42.2 (15.5) | 4.8 (2.5) | 4.3 (2.0) | 94 (20.3) | 1 (0.2) |
Metoprolol | 12.7 (5.3) | 12.2 (5.8) | 40.4 (18.0) | 43.8 (14.9) | 3.5 (1.5) | 3.9 (1.8) | 82 (17.7) | 18 (3.9) |