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Table 2 Demographic and clinical features of the MSA patients with and without camptocormia according to different disease durations

From: Camptocormia in patients with multiple system atrophy at different disease durations: frequency and related factors

Variables Disease duration ≤3 years Disease duration 3–5 years Disease duration ≥5 years
With camptocormia Without camptocormia P value With camptocormia Without camptocormia P value With camptocormia Without camptocormia P value
Number 42 (8.9%) 428 (91.1%) 34 (19.7%) 139 (80.3%) 14 (19.2%) 59 (80.8%)
Diagnosis (MSA-P/MSA-C) 26/16 185/243 0.020* 23/11 76/63 0.171 11/3 31/28 0.077
Sex (male/female) 17/25 238/190 0.060 20/14 81/58 0.953 9/5 40/19 0.802
Age 63.23 ± 7.94 58.65 ± 8.50 0.001* 63.79 ± 8.48 62.50 ± 9.65 0.539 65.11 ± 6.49 60.40 ± 9.87 0.073
Age of onset 61.38 ± 7.87 56.99 ± 8.51 0.001* 60.02 ± 8.17 58.72 ± 9.65 0.595 59.19 ± 6.96 54.27 ± 10.31 0.062
Disease duration 1.83 ± 0.74 1.59 ± 0.73 0.040 3.68 ± 0.58 3.76 ± 0.62 0.614 6.02 ± 1.13 6.14 ± 1.36 0.861
Educational year 9.38 ± 4.13 9.49 ± 3.90 0.809 9.03 ± 4.28 9.36 ± 3.71 0.523 9.14 ± 4.24 9.86 ± 4.29 0.572
Onset symptoms          
Autonomic symptom 13 134 0.094 10 58 0.146 5 27 0.608
Cerebellar symptom 8 143 5 29 2 11
Parkinsonism symptom 21 151 19 52 7 21
UMSARS-I 16.64 ± 6.28 12.35 ± 5.97 < 0.001*# 17.94 ± 7.33 16.54 ± 5.88 0.340 22.00 ± 9.72 17.56 ± 6.93 0.157
UMSARS-II 20.79 ± 6.85 15.15 ± 6.33 < 0.001*# 21.53 ± 8.18 18.72 ± 5.94 0.142 26.07 ± 7.36 18.66 ± 7.49 0.003*
UMSARS-IV 2.52 ± 1.04 1.72 ± 0.74 < 0.001*# 2.68 ± 1.17 2.22 ± 1.01 0.036 3.14 ± 1.46 2.46 ± 1.07 0.093
Total UMSARS score 37.43 ± 12.10 27.50 ± 11.41 < 0.001 *# 39.47 ± 14.93 35.26 ± 10.85 0.207 48.07 ± 16.31 36.22 ± 13.74 0.027
OH (yes/no) 10/32 107/321 0.865 13/21 43/96 0.415 5/9 20/39 1.000
Total score of FAB 12.81 ± 3.80 14.49 ± 2.93 0.007* 14.18 ± 2.71 14.22 ± 2.65 0.962 14.07 ± 3.85 14.56 ± 2.91 0.843
Total MOCA score 20.05 ± 6.51 21.79 ± 4.95 0.197 21.88 ± 4.99 21.36 ± 4.74 0.568 19.86 ± 6.60 21.81 ± 5.03 0.500
HDRS score 13.14 ± 7.86 10.39 ± 7.68 0.025* 13.24 ± 9.63 12.10 ± 7.57 0.748 15.64 ± 11.41 14.54 ± 8.43 0.972
HARS score 9.71 ± 6.63 8.69 ± 6.71 0.256 9.32 ± 7.65 10.75 ± 7.15 0.163 13.21 ± 7.91 11.73 ± 7.69 0.457
LEDD (mg/day) 135.12 ± 240.37 97.52 ± 204.27 0.347 256.61 ± 263.95 185.07 ± 262.41 0.070 318 ± 324.44 204.24 ± 338.86 0.118
  1. MSA multiple system atrophy, MSA-P multiple system atrophy with predominately parkinsonism, MSA-C multiple system atrophy with predominately cerebellar ataxia, UMSARS unified multiple system atrophy rating scale, OH orthostatic hypotension, FAB frontal lobe battery, MoCA Montreal cognitive assessment, HDRS Hamilton depression rating scale, HARS Hamilton anxiety rating scale, LEDD levodopa equivalent daily dose
  2. *: significant difference after adjusting by false discovery rate
  3. #: after adjusting for age of onset and disease duration