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Table 1 Basic characteristics and quality evaluation of the included studies

From: Prognostic value of the neutrophil-to-lymphocyte ratio in acute ischemic stroke patients treated with intravenous thrombolysis: a systematic review and meta-analysis

Author

Year

Country

Sample size

Male

(%)

Age(year)

Sample time

HT

PFO

Death

Cutoff value

Type of OR

NOS

Maestrini [19]

2015

France and Finland

846

50.8

71(61–80)

On admission

sICH

Yes

Yes

4.8 of sICH

Pooled

7

Guo [12]

2016

China

189

65.1

65.0 ± 10.6

12–18 h after IVT

sICH

NA

NA

10.59 of sICH

Pooled

7

Pagram [20]

2016

Australia

141

NA

74.3 ± 10.7

On admission,

24 h after IVT

NA

Yes

NA

NA

Pooled

6

Malhotra [21]

2018

USA

657

50.7

64.3 ± 14.4

On admission

sICH

Yes

Yes

2.2 of PFO

Crude

6

Shi [22]

2018

China

372

65.1

63.9 ± 13.3

On admission,

24 h after IVT

HT

Yes

Yes

NA

Pooled

8

Guo [24]

2018

China

105

64.8

65.7 ± 9.8

6–8 h after IVT

NA

Yes

NA

5.23 of PFO

Pooled

7

Wang [23]

2018

China

123

65.0

65.2 ± 11.9

On admission

NA

Yes

NA

3.375 of PFO

Pooled

7

Pektezel [25]

2019

Turkey

142

43.7

69 ± 13

On admission,

24 h after IVT

HT

Yes

NA

7.4 of HT,

3.6 of PFO

Pooled

7

Liu [27]

2020

China

285

70.5

62.3 ± 12

On admission

HT

NA

NA

NA

Pooled

7

Ying [11]

2020

China

208

61.5

67.4 ± 12.4

On admission,

24 h after IVT

PH

Yes

NA

NA

Pooled

7

Liu [28]

2020

China

192

71.9

60.8 ± 11.7

On admission

NA

Yes

NA

NA

Pooled

7

Cheng [26]

2020

China

481

61.9

68 (59–76)

24 h after IVT

NA

Yes

Yes

NA

Pooled

7

  1. HT hemorrhagic transformation, PFO poor functional outcome, OR odds ratio, NOS Newcastle-Ottawa Scale, sICH symptomatic intracranial hemorrhage, IVT intravenous thrombolysis, NA not available, PH parenchymal hemorrhage