Group | HT | 3-month poor functional outcome | ||||||
---|---|---|---|---|---|---|---|---|
N | OR (95%CI) | P | Heterogeneity (I², P) | N | OR (95%CI) | P | Heterogeneity (I², P) | |
Sample time | ||||||||
 On admission | 5 | 1.33 (1.01, 1.75) | 0.039 | 48.7%, 0.100 | 8 | 1.22 (1.05, 1.40) | 0.007 | 76.1%, <0.001 |
 Post-IVT | 4 | 1.88 (0.97, 3.63) | 0.061 | 84.7%, <0.001 | 6 | 2.78 (1.63, 4.74) | <0.001 | 84.3%, <0.001 |
Age | ||||||||
 <65 | 2 | 1.43 (0.98, 2.08) | 0.063 | 0.0%, 0.393 | 3 | 1.83 (1.01, 3.32) | 0.045 | 87.7%, <0.001 |
 ≥65 | 4 | 1.32 (1.11, 1.57) | 0.002 | 80.0%, <0.001 | 7 | 1.87 (1.36, 2.59) | <0.001 | 87.1%, <0.001 |
Country | ||||||||
 Asian | 5 | 1.68 (1.20, 2.35) | 0.003 | 73.2%, <0.001 | 7 | 1.82 (1.31, 2.53) | <0.001 | 75.5%, <0.001 |
 Non-Asian | 1 | 1.11 (1.06, 1.17) | <0.001 | -, - | 3 | 1.37 (1.12, 1.68) | 0.002 | 92.1%, <0.001 |
Infection excluded | ||||||||
 Yes | 4 | 1.64 (1.14, 2.35) | 0.008 | 74.2%, 0.001 | 6 | 1.75 (1.24, 2.48) | 0.002 | 75.9%, <0.001 |
 No | 2 | 1.39 (0.77, 2.51) | 0.274 | 71.4%, 0.062 | 4 | 1.50 (1.22, 1.85) | <0.001 | 91.5%, <0.001 |
Stroke severity | ||||||||
 NIHSS<8 | 2 | 1.69 (1.11, 2.56) | 0.014 | 30.4%, 0.238 | 4 | 1.34 (0.91, 1.96) | 0.135 | 70.7%, 0.008 |
 NIHSS≥8 | 4 | 1.25 (1.07, 1.47) | 0.006 | 76.1%, 0.001 | 6 | 2.15 (1.50, 3.09) | <0.001 | 89.9%, <0.001 |
Onset-to-IVT time | ||||||||
 ≤3h | 4 | 1.32 (1.11, 1.57) | 0.002 | 80.0%, <0.001 | 6 | 1.24 (1.09, 1.42) | 0.001 | 77.6%, <0.001 |
 3-4.5h | 2 | 1.43 (0.98, 2.08) | 0.063 | 0.0%, 0.393 | 3 | 2.52 (1.19, 5.30) | 0.015 | 78.0%, 0.003 |
Type of HT | ||||||||
 sICH | 2 | 1.12 (1.07, 1.17) | <0.001 | 0.0%, 0.558 | - | - | - | - |
 HT or PH | 4 | 1.84 (1.27, 2.66) | 0.001 | 57.0%, 0.030 | - | - | - | - |
Type of OR | ||||||||
 Pooled | 6 | 1.33 (1.14, 1.56) | <0.001 | 71.8%, <0.001 | 9 | 1.96 (1.46, 2.64) | <0.001 | 86.9%, <0.001 |
 Crude | 0 | - | - | - | 1 | 1.08 (1.02, 1.14) | 0.007 | -, - |