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Table 2 Subgroup analyses of the associations between NLR and poor prognosis in AIS patients treated with IVT

From: Prognostic value of the neutrophil-to-lymphocyte ratio in acute ischemic stroke patients treated with intravenous thrombolysis: a systematic review and meta-analysis

Group

HT

3-month poor functional outcome

N

OR (95%CI)

P

Heterogeneity (I², P)

N

OR (95%CI)

P

Heterogeneity (I², P)

Sample time

 On admission

5

1.33 (1.01, 1.75)

0.039

48.7%, 0.100

8

1.22 (1.05, 1.40)

0.007

76.1%, <0.001

 Post-IVT

4

1.88 (0.97, 3.63)

0.061

84.7%, <0.001

6

2.78 (1.63, 4.74)

<0.001

84.3%, <0.001

Age

 <65

2

1.43 (0.98, 2.08)

0.063

0.0%, 0.393

3

1.83 (1.01, 3.32)

0.045

87.7%, <0.001

 ≥65

4

1.32 (1.11, 1.57)

0.002

80.0%, <0.001

7

1.87 (1.36, 2.59)

<0.001

87.1%, <0.001

Country

 Asian

5

1.68 (1.20, 2.35)

0.003

73.2%, <0.001

7

1.82 (1.31, 2.53)

<0.001

75.5%, <0.001

 Non-Asian

1

1.11 (1.06, 1.17)

<0.001

-, -

3

1.37 (1.12, 1.68)

0.002

92.1%, <0.001

Infection excluded

 Yes

4

1.64 (1.14, 2.35)

0.008

74.2%, 0.001

6

1.75 (1.24, 2.48)

0.002

75.9%, <0.001

 No

2

1.39 (0.77, 2.51)

0.274

71.4%, 0.062

4

1.50 (1.22, 1.85)

<0.001

91.5%, <0.001

Stroke severity

 NIHSS<8

2

1.69 (1.11, 2.56)

0.014

30.4%, 0.238

4

1.34 (0.91, 1.96)

0.135

70.7%, 0.008

 NIHSS≥8

4

1.25 (1.07, 1.47)

0.006

76.1%, 0.001

6

2.15 (1.50, 3.09)

<0.001

89.9%, <0.001

Onset-to-IVT time

 ≤3h

4

1.32 (1.11, 1.57)

0.002

80.0%, <0.001

6

1.24 (1.09, 1.42)

0.001

77.6%, <0.001

 3-4.5h

2

1.43 (0.98, 2.08)

0.063

0.0%, 0.393

3

2.52 (1.19, 5.30)

0.015

78.0%, 0.003

Type of HT

 sICH

2

1.12 (1.07, 1.17)

<0.001

0.0%, 0.558

-

-

-

-

 HT or PH

4

1.84 (1.27, 2.66)

0.001

57.0%, 0.030

-

-

-

-

Type of OR

 Pooled

6

1.33 (1.14, 1.56)

<0.001

71.8%, <0.001

9

1.96 (1.46, 2.64)

<0.001

86.9%, <0.001

 Crude

0

-

-

-

1

1.08 (1.02, 1.14)

0.007

-, -

  1. NLR neutrophil to lymphocyte ratio, HT hemorrhagic transformation, AIS acute ischemic stroke, IVT intravenous thrombolysis, N number of studies, OR odds ratio, NIHSS National Institutes of Health Stroke Scale, sICH symptomatic intracerebral hemorrhage, PH parenchymal hemorrhage