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Table 1 The CNS/brain projects of TCGA database enrolled in the study retrieved by cBioPortal

From: BRAFnon-V600E more frequently co-occurs with IDH1/2 mutations in adult patients with gliomas than in patients harboring BRAFV600E but without a survival advantage

Project

All Samples

Samples with mutation data

Samples with BRAFV600E

Samples with BRAFnon-V600E

References

Diffuse Glioma

 Brain Lower Grade Glioma (TCGA, Firehose Legacy)

530

286

1

1

https://www.cancer.gov

 Brain Lower Grade Glioma (TCGA, PanCancer Atlas)

514

512

1

2

[24,25,26,27,28,29]

 Glioma (MSK, Nature 2019)

91

91

2

1

https://www.cancer.gov

 Glioma (MSKCC, Clin Cancer Res 2019)

1004

1004

22

19

[30]

 Low-Grade Gliomas (UCSF, Science 2014)

61

61

2

0

[31]

 Merged Cohort of LGG and GBM (TCGA, Cell 2016)

1102

812

5

2

[32]

GLIOBLASTOMA

 Brain Tumor PDXs (Mayo Clinic, 2019)

95

83

2

1

https://www.cbioportal.org

 Glioblastoma (Columbia, Nat Med. 2019)

42

32

1

1

[33]

 Glioblastoma (TCGA, Cell 2013)

543

257

3

0

[34]

 Glioblastoma (TCGA, Nature 2008)

206

91

0

0

[35]

 Glioblastoma Multiforme (TCGA, Firehose Legacy)

604

290

5

1

https://www.cancer.gov

 Glioblastoma Multiforme (TCGA, PanCancer Atlas)

592

397

5

3

[24,25,26,27,28,29, 36]

OLIGODENDROGLIOMA

 Anaplastic Oligodendroglioma and Anaplastic Oligogastrocytoma (MSKCC, Neuro Oncol 2017)

22

22

0

0

[37]

Embryonal Tumor

 MEDULLOBLASTOMA

  Medulloblastoma (Broad, Nature 2012)

92

92

0

0

[38]

  Medulloblastoma (ICGC, Nature 2012)

125

125

0

0

[39]

  Medulloblastoma (PCGP, Nature 2012)

37

37

0

0

[40]

  Medulloblastoma (Sickkids, Nature 2016)

46

46

0

1

[41]

Encaspulated Glioma

 PILOCYTIC ASTROCYTOMA

  Pilocytic Astrocytoma (ICGC, Nature Genetics 2013)

96

96

4

3

[42]

Miscellaneous Neuroepithelial Tumor

 Pheochromocytoma and Paraganglioma (TCGA, Cell 2017)

178

178

0

1

[43]

 Pheochromocytoma and Paraganglioma (TCGA, Firehose Legacy)

184

162

0

1

https://www.cancer.gov