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Table 3 Medians (inter-quartile ranges) of outcome measures, on enrolment (before PBM treatment) and after PBM treatment for both groups

From: Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study

 

On enrolment (n = 12)

After 12 weeks of clinic-treatment (n = 12)

After 25 or 40 weeks of home-treatment (n = 10)

Mobility tests

 10MWT walk speed (m/s)

1.12 (0.29)

1.70 (0.35)**

1.74 (0.41)

 10MWT stride length (m)

0.52 (0.06)

0.67 (0.11)**

0.75 (0.06)

 TUG (s)

8.0 (1.6)

7.1 (1.3)**

6.58 (1.9)**

 TUG motor (s)

8.6 (3.2)

7.6 (2.0)**

10.4 (2.5)*

 TUG cognitive (s)

10.4 (2.5)

6.9 (2.3)**

9.5 (5.1)**

Dynamic Balance test

 Step test - affected leg (n)

12.0 (5.0)

16.5 (4.5)**

17.5 (5.3)**

 Step test - unaffected leg (n)

12.0 (2.0)

15.5 (4.8)**

19.5 (6.3)**

Cognition test

 MoCA

26 (3.0)

28 (2.0)**

29.9 (1.0)**

Fine Motor Skill tests

 NHPT - affected hand (s)

22.8 (4.0)

27.5 (7.5)

23.9 (7.0)

 NHPT - unaffected hand (s)

23.3 (6.0)

24.0 (7.2)

23.2 (6.2)

 Spiral test - dominant hand (s)

30.9 (11.0)

27.3 (10.6)**

23.4 (9.3)* n = 11

Static Balance tests

 TS affected leg behind (s)

2.0 (6.50)

5.8 (17.00)*

3.9 (26.6) n = 9

 TS unaffected leg behind (s)

1.5 (4.75)

2.75 (19.08)

3.9 (26.8) n = 9

 SLS affected leg raised (s)

2.0 (4.5)

0.8 (3.3)

4.5 (2.8) n = 6

 SLS unaffected leg raised (s)

1.5 (2.0)

1.4 (3.4)

24.5 (21.5) n = 6

  1. Significant improvement in outcome measure compared to before PBM treatment - * p < 0.05 ** p < 0.01
  2. 10MWT 10 m walk test, TUG timed up-and-go, MoCA Montreal Cognitive Assessment, NHPT nine-hole peg test, TS tandem stance (eyes closed), SLS single leg stance (eyes closed)