Fig. 2

Some auxiliary examination results of the patients. Non-contrast computed tomography of the head showed predominant right temporal hypodensity with extensive edema and several calcifications (yellow arrows) (a). Hematoxylin- and eosin-stained histological section of the white matter of the brain (scale bar, 100 µm) revealed leukoaraiosis and neuropil edema, infiltrated by gitter cells, as well as vessel wall thickening with varying degrees of luminal narrowing. Some vessels were surrounded by lymphocytes (b). Masson stain of brain section (scale bar, 50 µm) showed small artery wall thickening with a proliferation of collagen fibers (blue) and formation of hyaline thrombi (c). Fluorescein angiography revealed extensive areas of capillary obliteration with non-perfusion (yellow arrow), and profuse leakage from the membrane on the disc (yellow asterisk) (d). Diffusion weighted image of the brain showed central diffusion restriction of the lesions in left temporal-occipital lobe and right temporal lobe (e). Susceptibility weighted axial images showed microbleeds in the lesions (f)