HR subgroup | Number of events/at risk, % | Unadjusted | Â | Â | Multivariate-adjusted | Â | Â |
---|---|---|---|---|---|---|---|
 |  | OR | 95% CI | P value | OR | 95% CI | P value |
Mean HR | |||||||
 G1 (< 70 bpm) | 119/570 (21) | 1.00 | Reference | … | 1.00 | Reference | … |
 G2 (≥ 70 and < 80 bpm) | 153/404 (38) | 2.31 | 1.74 − 3.07 |  < 0.001 | 1.81 | 1.25 − 2.61 | 0.002 |
 G3 (≥ 80 and < 90 bpm) | 129/262 (49) | 3.68 | 2.68 − 5.04 |  < 0.001 | 2.52 | 1.66 − 3.82 |  < 0.001 |
 G4 (≥ 90 bpm) | 134/184 (73) | 10.16 | 6.93 − 14.89 |  < 0.001 | 3.88 | 2.20 − 6.85 |  < 0.001 |
 P for trend |  |  |  |  < 0.001 |  |  |  < 0.001 |
HR-CV | |||||||
 G1 (< 0.08) | 124/397 (31) | 1.00 | Reference | … | 1.00 | Reference | … |
 G2 (> 0.08 and < 0.10) | 108/305 (35) | 1.21 | 0.88 − 1.66 | 0.244 | 1.32 | 0.87 − 2.00 | 0.192 |
 G3 (≥ 0.10 and < 0.12) | 94/236 (40) | 1.46 | 1.04 − 2.04 | 0.028 | 1.10 | 0.69 − 1.75 | 0.700 |
 G4 (≥ 0.12) | 209/482 (43) | 1.69 | 1.28 − 2.23 |  < 0.001 | 1.47 | 1.00 − 2.16 | 0.051 |
 P for trend |  |  |  | 0.002 |  |  | 0.224 |