HR subgroup | Number of events/at risk, % | Unadjusted | Â | Â | Multivariate-adjusted | Â | Â |
---|---|---|---|---|---|---|---|
 |  | OR | 95% CI | P value | OR | 95% CI | P value |
Mean HR | |||||||
 G1 (< 70 bpm) | 97/424 (23) | 1.00 | Reference | … | 1.00 | Reference | … |
 G2 (≥ 70 and < 80 bpm) | 122/314 (39) | 2.14 | 1.55 − 2.95 |  < 0.001 | 1.80 | 1.18 − 2.73 | 0.006 |
 G3 (≥ 80 and < 90 bpm) | 102/208 (49) | 3.24 | 2.28 − 4.62 |  < 0.001 | 2.35 | 1.47 − 3.76 |  < 0.001 |
 G4 (≥ 90 bpm) | 95/130 (73) | 9.15 | 5.84 − 14.34 |  < 0.001 | 2.96 | 1.51 − 5.81 | 0.002 |
 P for trend |  |  |  |  < 0.001 |  |  |  < 0.001 |
HR-CV | |||||||
 G1 (< 0.08) | 99/310 (32) | 1.00 | Reference | … | 1.00 | Reference | … |
 G2 (> 0.08 and < 0.10) | 89/238 (37) | 1.27 | 0.89 − 1.82 | 0.182 | 1.59 | 0.99 − 2.54 | 0.053 |
 G3 (≥ 0.10 and < 0.12) | 69/170 (41) | 1.46 | 0.99 − 2.15 | 0.058 | 1.40 | 0.81 − 2.40 | 0.227 |
 G4 (≥ 0.12) | 159/358 (44) | 1.70 | 1.24 − 2.34 | 0.001 | 1.73 | 1.11 − 2.70 | 0.015 |
 P for trend |  |  |  | 0.010 |  |  | 0.086 |