From: Late-onset neuromuscular disorders in the differential diagnosis of sarcopenia
Disease | Sarcopenia | ALS | IBM | DM2 |
---|---|---|---|---|
Prevalencea | ≈ 8500b | ≈ 5 | ≈ 5c | ≈ 10 |
Age at onset [years] | ≈ 65 | ≈ 50–70 | ≈ 65 | ≈ 50-70d |
Disease-Onset | symmetrical, generalized, slow progressive | asymmetrical, distal, fast progressive generalized including ventilatory insufficiency | asymmetrical, start frequently weakness of finger flexors, later dysphagia | symmetrical, proximal, axial > distal, cataract, arrhythmia, heart failure |
Disease pattern |
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Outcome | Reduced life expectancy by falls and fractures | Lethal within 3–10 years | Disabling within 10–20 years | Normal life expectancy |