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Table 1 Disease characteristics

From: Late-onset neuromuscular disorders in the differential diagnosis of sarcopenia

Disease Sarcopenia ALS IBM DM2
Prevalencea ≈ 8500b ≈ 5 ≈ 5c ≈ 10
Age at onset [years] ≈ 65 ≈ 50–70 ≈ 65 ≈ 50-70d
Disease-Onset symmetrical, generalized, slow progressive asymmetrical, distal, fast progressive generalized including ventilatory insufficiency asymmetrical, start frequently weakness of finger flexors, later dysphagia symmetrical, proximal, axial > distal, cataract, arrhythmia, heart failure
Disease pattern
Outcome Reduced life expectancy by falls and fractures Lethal within 3–10 years Disabling within 10–20 years Normal life expectancy
  1. References: [1, 2, 4, 6, 11, 12, 15,16,17,18]
  2. ALS   amyotrophic lateral sclerosis, DM2  myotonic dystrophy type 2, IBM  inclusion body myositis
  3. aPrevalence per 100,000 population; bhigher prevalence in older people; cin population older than 50 years; d: muscle weakness onset;