Characteristic Type | Pimavanserin (n = 153) | Quetiapine (n = 2452) | Aripiprazole (n = 169) | Risperidone (n = 462) | Olanzapine (n = 304) | p-value | |
---|---|---|---|---|---|---|---|
Demographic | Age at initiation, years median (IQR) | 75 (69–80) | 77 (69–82) | 72 (64–78) | 78 (72–83) | 76 (70–82) | < 0.0001b |
Age groups, n (col%) | < 0.0001a | ||||||
40–59 years | 4 (2.6) | 166 (6.8) | 18 (10.7) | 21 (4.5) | 22 (7.2) | ||
60 to 79 years | 108 (70.6) | 1389 (56.6) | 119 (70.4) | 249 (53.9) | 179 (58.9) | ||
≥80 years | 41 (26.8) | 897 (36.6) | 32 (18.9) | 192 (41.6) | 103 (33.9) | ||
Sex categories, n (col%) | < 0.0001a | ||||||
Male | 94 (61.4) | 1429 (58.3) | 54 (32.0) | 225 (48.7) | 155 (51.0) | ||
Female | 59 (38.6) | 1023 (41.7) | 115 (68.0) | 237 (51.3) | 149 (49.0) | ||
Race categories, n (col%) | 0.268a | ||||||
White | 96 (62.7) | 1542 (62.9) | 111 (65.7) | 277 (60.0) | 198 (65.1) | ||
Nonwhite | 31 (20.3) | 450 (18.3) | 27 (16.0) | 100 (21.6) | 41 (13.5) | ||
Unknown/Missing | 26 (17.0) | 460 (18.8) | 31 (18.3) | 85 (18.4) | 65 (21.4) | ||
Region, n (col %) | 0.194a | ||||||
Midwest | 28 (18.3) | 515 (21.0) | 37 (21.9) | 102 (22.1) | 70 (23.0) | ||
Northeast | 12 (7.8) | 287 (11.7) | 22 (13.0) | 63 (13.6) | 31 (10.2) | ||
South | 70 (45.8) | 984 (40.1) | 81 (47.9) | 183 (39.6) | 115 (37.8) | ||
West | 42 (27.4) | 657 (26.8) | 29 (17.2) | 114 (24.7) | 88 (28.9) | ||
Other | 1 (0.6) | 9 (0.4) | 0 (0) | 0 (0) | 0 (0) | ||
Clinical | Combined Charlson-Elixhauser comorbidity score, mean (SD) | 1.6 (1.9) | 1.9 (2.4) | 1.9 (2.1) | 2.2 (2.5) | 2.2 (2.4) | 0.0002b |
Claims-based frailty index, mean (SD) | 0.20 (0.05) | 0.22 (0.06) | 0.22 (0.06) | 0.23 (0.07) | 0.23 (0.07) | < 0.0001b | |
CFI categories, n (col%) | < 0.0001a | ||||||
Robust | 24 (15.7) | 301 (12.3) | 15 (8.9) | 40 (8.6) | 28 (9.2) | ||
Prefrail | 104 (68.0) | 1526 (62.2) | 100 (59.2) | 253 (54.8) | 173 (56.9) | ||
Mildly frail | 20 (13.1) | 514 (21.0) | 48 (28.4) | 149 (32.3) | 84 (27.6) | ||
Moderate to severely frail | 5 (3.3) | 111 (4.5) | 6 (3.5) | 20 (4.3) | 19 (6.3) | ||
Healthcare and medication use in 6 months prior to AP initiation | # Medications filled per month, mean (SD) | 3.5 (1.8) | 4.1 (2.4) | 5.4 (2.7) | 4.5 (2.5) | 4.5 (2.5) | < 0.0001b |
# Neurology visits, mean (SD) | 1.3 (1.2) | 1.2 (1.6) | 0.9 (1.2) | 1.0 (2.7) | 0.9 (1.3) | < 0.0001b | |
# ED visits, mean (SD) | 0.3 (0.7) | 0.5 (1.4) | 0.8 (2.5) | 0.6 (1.2) | 0.7 (2.2) | 0.0484b | |
# Inpatient admissions, mean (SD) | 0.5 (3.3) | 1.3 (4.0) | 1.4 (3.6) | 2.2 (6.9) | 2.0 (5.1) | < 0.0001b |