Fig. 2

Skin biopsy findings at the age of 60. Eosinophilic and p62-positive intranuclear inclusions in adipocytes (a, b) and sweat gland cells (c, d). Electron microscopy of an inclusion body in the fibroblast nucleus revealed that it consisted of tubule-filamentous material but without a limiting membrane (e, f). Staining: a, c hematoxylin and eosin; b, d anti-p62 immunohistochemical staining. Scale bars: a-d 10 μm; e 2 μm; f 200 nm