Fig. 5

Pre-operative thalamus Cho/Cr and NAA/Cr in healthy controls (HC) and TN patients sorted by surgical outcome. (A) Compared to healthy controls (HC), Cho/Cr in non-responders (Non-Res—dark grey bars) is reduced ipsilateral (Ips) to the side-of-pain (p = 0.038). There are no between-side differences in thalamus Cho/Cr for either responders (Res—light grey bars) or non-responders. (C) There are no between-group or within-group between-side (Ips vs. Cont) differences in thalamus NAA/Cr. Left vs. right interhemispheric % difference for Cho/Cr (B) or NAA/Cr (D) does not differ between responders (R) and non-responders (NR). Mann–Whitney tests were used to perform between-group comparisons, while Wilcoxon sign-rank tests were used to compare thalamus volumes within-groups. Statistical significance (p < 0.05) is indicated with *. Medians with interquartile ranges are displayed