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Fig. 2 | BMC Neurology

Fig. 2

From: A case report of secondary neurolymphomatosis showing selective nerve infiltration and massive lumbar plexus enlargement

Fig. 2

Histopathological features of the cauda equina biopsy specimen. Medium-to-large lymphoid cells filled the subdural space to the subarachnoid interstitial tissue and infiltrated peripheral nerve bundles (A-C). Nerve fibers (labeled ā€œNā€) were identified by S100 staining (polyclonal, ready to use (RTU), Leica biosystems, Wetzlar, Germany) (C). Immunostaining of atypical lymphoid cells showed a positive reaction for CD20 (clone L26, RTU, Leica) and CD10 (clone 56C6, RTU, Leica) and a negative reaction for CD56 (clone CD564, RTU, Leica), consistent with a diagnosis of diffuse large B-cell lymphoma of the germinal center B-cell subtype (D-F)

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