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Table 1 Demographic and clinical characteristics of the study population and healthy controls

From: Hepatitis E virus as a trigger for Guillain-Barré syndrome

  GBS
(n = 163)
Healthy controls
(n = 263)
Median age in years (SD; range) 59 (17;18–87) 28 (15;18–89)
Sex:
 Male 95 (58.3) 119 (45.2)
 Female 68 (41.7) 144 (54.8)
GBS Variants:
 Classical GBS 140 (85.9) n.a.
  sensorimotor 93 (57.1)
  pure motor 22 (13.5)
  pure sensory 5 (3.1)
  paraparetic 10 (6.1)
  Pharyngeal-cervical-brachial 2 (1.2)
  Bilateral facial palsy with paraesthesias 8 (4.9)
Miller-Fisher syndrome (MFS) 22 (13.5)
MFS-GBS overlap 1 (0.6)
GBS disability score at nadir:
Mean (SD) 3.2 ± 1.2 n.a.
Median 3.0
  0 - Healthy
  1 - Minor signs or symptoms of neuropathy, capable of manual work 12 (7.4)
  2 - Able to walk without support of a stick but incapable of manual work 39 (23.9)
  3 - Able to walk with a stick, appliance or support 42 (25.8)
  4 - Confined to bed or wheelchair-bound 49 (30.1)
  5 - Requiring assisted ventilation 21 (12.9)
  6 - Dead
CSF analysis (n = 161):
 Albuminocytological dissociation 113 (70.2)  
 Slightly increased cell count (5–50/μl) and increased protein level 26 (16.2)
 Increased cell count (50–100/μl) and increased protein level 2 (1.2)
 Normal 20 (12.4)
Electrophysiological testing:   
 Pathological 144 (88.3)
  AIDP 31 (19.0)
  Axonal-demyelinating subtype 55 (33.7)
  Predominantly demyelinating subtype 22 (13.5)
  Predominantly axonal subtype 11 (6.8)
  AMAN 7 (4.3)
  AMSAN 9 (5.5)
  Not classifiable 9 (5.5)
  Normal 19 (11.7)
  1. Data are listed as numbers (%) unless indicated otherwise
  2. AIDP acute inflammatory demyelinating polyradiculoneuropathy, AMAN acute motor axonal neuropathy, AMSAN acute motor sensory axonal neuropathy CSF cerebrospinal fluid, GBS Guillain-Barré Syndrome, n.a. not applicable, n number, SD standard deviation