From: Hepatitis E virus as a trigger for Guillain-Barré syndrome
GBS (n = 163) | Healthy controls (n = 263) | |
---|---|---|
Median age in years (SD; range) | 59 (17;18–87) | 28 (15;18–89) |
Sex: | ||
Male | 95 (58.3) | 119 (45.2) |
Female | 68 (41.7) | 144 (54.8) |
GBS Variants: | ||
Classical GBS | 140 (85.9) | n.a. |
sensorimotor | 93 (57.1) | |
pure motor | 22 (13.5) | |
pure sensory | 5 (3.1) | |
paraparetic | 10 (6.1) | |
Pharyngeal-cervical-brachial | 2 (1.2) | |
Bilateral facial palsy with paraesthesias | 8 (4.9) | |
Miller-Fisher syndrome (MFS) | 22 (13.5) | |
MFS-GBS overlap | 1 (0.6) | |
GBS disability score at nadir: | ||
Mean (SD) | 3.2 ± 1.2 | n.a. |
Median | 3.0 | |
0 - Healthy | – | |
1 - Minor signs or symptoms of neuropathy, capable of manual work | 12 (7.4) | |
2 - Able to walk without support of a stick but incapable of manual work | 39 (23.9) | |
3 - Able to walk with a stick, appliance or support | 42 (25.8) | |
4 - Confined to bed or wheelchair-bound | 49 (30.1) | |
5 - Requiring assisted ventilation | 21 (12.9) | |
6 - Dead | – | |
CSF analysis (n = 161): | ||
Albuminocytological dissociation | 113 (70.2) | |
Slightly increased cell count (5–50/μl) and increased protein level | 26 (16.2) | |
Increased cell count (50–100/μl) and increased protein level | 2 (1.2) | |
Normal | 20 (12.4) | |
Electrophysiological testing: | ||
Pathological | 144 (88.3) | |
AIDP | 31 (19.0) | |
Axonal-demyelinating subtype | 55 (33.7) | |
Predominantly demyelinating subtype | 22 (13.5) | |
Predominantly axonal subtype | 11 (6.8) | |
AMAN | 7 (4.3) | |
AMSAN | 9 (5.5) | |
Not classifiable | 9 (5.5) | |
Normal | 19 (11.7) |