Characteristic | Crude OR (95% CI) | p –value | Adjusted OR (95% CI) | p- value |
---|---|---|---|---|
Patient related factors | ||||
Age(years) | ||||
5-9 | 1 | 1 | ||
10-14 | 2.43 (0.97- 6.07) | 0.06 | 2.52 (0.74 – 8.56) | 0.11 |
15-18 | 2.46 ( 1.03 – 5.87) | 0.04 | 3.68 ( 1.08 – 12.49) | 0.18 |
Sex | ||||
Male | 0.96 (0.53 – 1.73) | 0.9 | - | - |
Female | 1 | |||
Mean Hemoglobin(g/dl) | 1.01 ( 0.84 – 1.19) | 0.96 | - | - |
BMI (kg/m2) | ||||
Normal | 1 | |||
Underweight | 0.7 ( 0.38 – 1.28) | 0.25 | - | - |
Height/Age | ||||
Normal | 1 | |||
Stunting | 1.38 ( 0.77 – 2.47) | 0.26 | - | - |
Disease related factors | ||||
CD4 counts(cells/mm3) | ||||
< 200 | 14.4 ( 6.78 – 30.41) | 0.0001 | 5.21 ( 2.0 – 13.57) | 0.001 |
≥ 200 | 1 | 1 | ||
Viral Load (copies/ml) | ||||
< 1000 | 1 | 1 | ||
≥ 1000 | 23.13 ( 10.01 -53.34 ) | 0.0001 | 26.31 (7.91 – 86.51) | 0.0001 |
WHO clinical stage | ||||
1 & 2 | 1 | 1 | ||
3 & 4 | 3.7 ( 1.62 -8.46 ) | 0.002 | 0.43 (0.12 – 1.58) | 0.21 |
Duration of HIV illness( years) | 1.0 ( 0.95 – 1.07) | 0.73 | - | - |
Drug related factors | ||||
ARV drug combinations | ||||
NRTI + NNRTI | 0.89 ( 0.37 – 2.13) | 0.79 | 1.13 (0.32 – 4.01) | 0.84 |
NRTI + PI | 2.33 ( 1.21 – 4.49) | 0.01 | 5.67 (2.11– 15.22) | 0.01 |
NNRTI + DTG | 1 | 1 | ||
Duration of ARV use(years) | 1.01 ( 0.95 – 1.07) | 0.72 | - | - |
Isoniazid Exposure | ||||
Yes | 0.01 ( 0 - ∞ ) | 0.99 | - | - |
No | 1 | |||
Time interval since last use of Isoniazid | ||||
< 6 months | 1 | 1 | ||
≥ 6 months | 2.78 (1.38 – 5.61) | 0.004 | 4.54 (1.91-10.79) | 0.001 |
Cotrimoxazole Prophylaxis | ||||
Yes | 0.76 (0.26 – 2.27) | 0.63 | - | - |
No | 1 |