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Table 4 Univariate and multivariate analysis of factors associated with HIV - PN

From: Peripheral neuropathy in HIV-infected children attending care and treatment clinic, at Muhimbili National Hospital, Dar es Salaam: a cross sectional study

Characteristic

Crude OR (95% CI)

p –value

Adjusted OR (95% CI)

p- value

Patient related factors

Age(years)

  5-9

1

 

1

 

  10-14

2.43 (0.97- 6.07)

0.06

2.52 (0.74 – 8.56)

0.11

  15-18

2.46 ( 1.03 – 5.87)

0.04

3.68 ( 1.08 – 12.49)

0.18

Sex

  Male

0.96 (0.53 – 1.73)

0.9

-

-

  Female

1

   

Mean Hemoglobin(g/dl)

1.01 ( 0.84 – 1.19)

0.96

-

-

BMI (kg/m2)

  Normal

1

   

  Underweight

0.7 ( 0.38 – 1.28)

0.25

-

-

Height/Age

  Normal

1

   

  Stunting

1.38 ( 0.77 – 2.47)

0.26

-

-

Disease related factors

CD4 counts(cells/mm3)

  < 200

14.4 ( 6.78 – 30.41)

0.0001

5.21 ( 2.0 – 13.57)

0.001

  ≥ 200

1

 

1

 

Viral Load (copies/ml)

  < 1000

1

 

1

 

  ≥ 1000

23.13 ( 10.01 -53.34 )

0.0001

26.31 (7.91 – 86.51)

0.0001

WHO clinical stage

  1 & 2

1

 

1

 

  3 & 4

3.7 ( 1.62 -8.46 )

0.002

0.43 (0.12 – 1.58)

0.21

Duration of HIV illness( years)

1.0 ( 0.95 – 1.07)

0.73

-

-

Drug related factors

ARV drug combinations

  NRTI + NNRTI

0.89 ( 0.37 – 2.13)

0.79

1.13 (0.32 – 4.01)

0.84

  NRTI + PI

2.33 ( 1.21 – 4.49)

0.01

5.67 (2.11– 15.22)

0.01

  NNRTI + DTG

1

 

1

 

Duration of ARV use(years)

1.01 ( 0.95 – 1.07)

0.72

-

-

Isoniazid Exposure

  Yes

0.01 ( 0 - ∞ )

0.99

-

-

  No

1

   

Time interval since last use of Isoniazid

  < 6 months

1

 

1

 

  ≥ 6 months

2.78 (1.38 – 5.61)

0.004

4.54 (1.91-10.79)

0.001

Cotrimoxazole Prophylaxis

  Yes

0.76 (0.26 – 2.27)

0.63

-

-

  No

1