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Table 1 Baseline characteristics of the patients

From: Prognostic factors of adult tuberculous meningitis in intensive care unit: a single-center retrospective study in East China

Variables

All patients (n = 80)

Unfavorable outcome (n = 39)

Favorable outcome (n = 41)

P value

Demographic features

 Male sex

45 (56.3)

18 (46.2)

27 (65.9)

0.31

 Age,years

38.5 (18–79)

44 (20–79)

36 (18–76)

0.31

Clinical features

 History of tuberculosis infection

7 (8.8)

5 (12.8)

2 (4.9)

0.26

 Active extra-neural tuberculosis

41 (51.3)

20 (51.3)

21 (51.2)

> 0.99

 Immune deficiency

15 (18.8)

10 (25.6)

5 (12.2)

0.16

 Duration of symptoms, days

20 (3-365)

20 (6-365)

20 (3-365)

0.42

 Length of ICU stay, days

12.5 (1-207)

9 (1-207)

15 (5-149)

0.03

 Headache

59 (73.8)

31 (79.5)

28 (68.3)

0.31

 Irritability

23 (28.8)

6 (15.4)

17 (41.5)

0.01

 Nausea and vomiting

47 (58.8)

23 (59.0)

24 (58.5)

> 0.99

 Fever (≥ 38.5℃)

60 (75.0)

28 (71.8)

32 (78.0)

0.61

 Neck stiffness

67 (83.8)

32 (82.1)

35 (85.4)

0.77

 Convulsions

15 (18.8)

9 (23.1)

6 (14.6)

0.40

 Focal neurological deficits

43 (53.8)

20 (51.3)

23 (56.1)

0.82

 Altered consciousness

70 (87.5)

33 (84.6)

37 (90.2)

0.51

 Lethargy

68 (85.0)

32 (82.1)

36 (87.8)

0.54

GCS

3 (3–10)

3 (3–8)

3 (3–10)

0.06

APACHE II

23 (10–37)

26 (12–37)

20 (10–33)

0.003

SOFA

7 (3–13)

7 (4–13)

6 (3–11)

0.03

Laboratory results

 Positive culture in CSF

22 (27.8)

13 (34.2)a

9 (22.0)

0.32

 Positive AFB in CSF

1 (1.3)

1 (2.8)b

0 (0.0)

0.47

 Positive PCR in CSF

21 (26.9)

11 (29.7)c

10 (24.4)

0.62

 CSF glucose, mmol/L

2.32 (0.33–12.60)

2.30 (0.33–12.60)

2.40 (0.40-5.00)

0.79

 CSF/blood glucose ratio

0.32 (0.03–0.70)

0.33 (0.03–0.70)

0.30 (0.05–0.68)

0.82

 CSF protein level, mg/L

1462 (299–3816)

1471 (299–3188)

1453 (464–3816)

0.31

 CSF leukocyte, /µl

104 (2-1268)

108 (4-768)

102 (2-1268)

0.88

 Peripheral blood leukocyte, /µl

10,045 (3420–40,400)

10,070 (3420–40,400)

9780 (3470–26,020)

0.36

 Serum sodium, mmol/L

137 (107–158)

137 (117–158)

137 (107–154)

0.67

Cranial CT

 Hydrocephalus

45 (61.6)

25 (71.4) d

20 (52.6) e

0.15

 Basal meningeal enhancement

10 (13.7)

5 (14.3) d

5 (13.2) e

> 0.99

 Infarct

36 (49.3)

20 (57.1) d

16 (42.1) e

0.25

 Tuberculoma

4 (5.5)

3 (8.6) d

1 (2.6) e

0.34

 Pre-contrast basal  hyperdensity

6 (8.2)

4 (11.4) d

2 (5.3) e

0.42

 Mechanical ventilation

58 (72.5)

37 (94.9)

21 (51.2)

< 0.001

 Surgical intervention

11 (13.8)

7 (17.9)

4 (9.8)

0.34

  1. Data are presented as median (range) or numbers (percentages)
  2. Abbreviations: AFB acid-fast bacilli, APACHE acute physiology and chronic health evaluation, CSF cerebrospinal fluid, CT computed tomography, GCS Glasgow coma scale, ICU intensive care unit, PCR polymerase chain reaction, SOFA sequential organ failure assessment
  3. aData missed in 1 case
  4. bData missed in 3 cases
  5. cData missed in 2 cases
  6. dData missed in 4 cases
  7. eData missed in 3 cases