Prognostic factors of adult tuberculous meningitis in intensive care unit: a single-center retrospective study in East China

Table 3 Factors associated with outcome by univariate logistic regression analysis

Variable	Unfav	Fav	OR (95 % CI)	P Value	Variable	Unfav	Fav	OR (95 % CI)	P Value
Sex					Headache
Male	18	27	0.44 (0.18–1.10)	0.08	Yes	31	28	1.80 (0.65–4.98)	0.26
Female	21	14			No	8	13
Age, years					Irritability
> 60	10	6	2.01 (0.65–6.20)	0.22	Yes	6	17	0.26 (0.09–0.75)	0.01
≤ 60	29	35			No	33	24
Duration of Symptoms, days					Nausea and vomiting
> 10	32	30	1.68 (0.58–4.89)	0.34	Yes	23	24	1.02 (0.42–2.48)	0.97
≤ 10	7	11			No	16	17
ICU stay, days					Fever(≥ 38.5℃)
> 15	12	18	0.57 (0.23–1.42)	0.23	Yes	28	32	0.72 (0.26–1.98)	0.52
≤ 15	27	23			No	11	9
Immune deficiency					Neck stiffness
Yes	10	5	2.48 (0.76–8.08)	0.13	Yes	32	35	0.78 (0.24–2.58)	0.69
No	29	36			No	7	6
Old tuberculosis					Convulsions
Yes	5	2	2.87 (0.52–15.75)	0.23	Yes	9	6	1.75 (0.56–5.49)	0.34
No	34	39			No	30	35
Active extra-neuraltuberculosis					Focal neurologicaldeficits
Yes	20	21	0.95 (0.39–2.30)	0.91	Yes	20	23	1.21 (0.50–2.93)	0.67
No	19	20			No	19	18
Alteredconsciousness					Basal meningealenhancement
Yes	33	37	0.60 (0.15–2.29)	0.45	Yes	5	5	1.10 (0.29–4.18)	0.89
No	6	4			No	30	33
Lethargy					Hydrocephalus
Yes	32	36	0.64 (0.18–2.20)	0.47	Yes	25	20	2.25 (0.85–5.94)	0.10
No	7	5			No	10	18
GCS					Infarct
≤ 4	32	29	1.89 (0.66–5.45)	0.24	Yes	20	16	1.83 (0.72–4.64)	0.20
> 4	7	12			No	15	22
APACHE II					Tuberculoma
≤ 23	13	29	0.21 (0.08–0.53)	0.001	Yes	3	1	3.47 (0.34–35.02)	0.29
> 23	26	12			No	32	37
SOFA					MV
≤ 8	23	39	0.07 (0.02–0.35)	0.001	Yes	37	21	17.62(3.74–82.93)	< 0.001
> 8	16	2			No	2	20
Positive culture inCSF					Pre-contrast basalhyperdensity
Yes	13	9	1.85 (0.68–5.02)	0.23	Yes	4	2	2.32 (0.40-13.55)	0.35
No	25	32			No	31	36
Positive PCR in CSF					Surgical intervention
Yes	11	10	1.31 (0.48–3.57)	0.60	Yes	7	4	2.02 (0.54–7.55)	0.29
No	26	31			No	32	37

Abbreviations: APACHE acute physiology and chronic health evaluation, CI confidence interval, CSF cerebrospinal fluid, Fav favorable, GCS Glasgow coma scale, ICU intensive care unit, MV mechanical ventilation, OR odds ratio, PCR polymerase chain reaction, SOFA sequential organ failure assessment, Unfav unfavorable

ISSN: 1471-2377