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Table 2 The association between biomarkers and total sedentary time

From: Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study

 

Crude

Adjusteda

β

95%CI

P

β

95%CI

P

hsCRP

     

R2 = 0.16

 Total sedentary time

0.32

(0.18, 0.47)

< 0.001

0.25

(0.09, 0.39)

0.001

IL-6b

     

R2 = 0.12

 Total sedentary time

0.26

(0.14, 0.38)

< 0.001

0.17

(0.04, 0.30)

0.009

IL-10b

     

R2 = 0.04

 Total sedentary time

0.04

(−0.09, 0.16)

0.509

0.01

(− 0.12, 0.14)

0.841

Neopterin

     

R2 = 0.35

 Total sedentary time

0.24

(0.12, 0.36)

< 0.001

0.12

(0.00, 0.22)

0.034

PAr-index

     

R2 = 0.37

 Total sedentary time

0.33

(0.22, 0.45)

< 0.001

0.21

(0.09, 0.30)

< 0.001

KTR

     

R2 = 0.45

 Total sedentary time

0.21

(0.09, 0.33)

0.001

0.06

(−0.05, 0.15)

0.238

KA

     

R2 = 0.48

 Total sedentary time

0.04

(−0.08, 0.16)

0.512

−0.10

(−0.21, − 0.02)

0.045

  1. hsCRP = high sensitive C-reactive protein. IL-6 = interleukin-6. IL-10 = interleukin-10, PAr-index = (4-pyridoxic acid/(pyridoxal 5′-phosphate + pyridoxal). KTR = kynurenine/tryptophan ratio = (kynurenine nM/tryptophan μM), KA = kynurenic acid
  2. aModel: biomarker is the dependent variable. Sedentary time, age, sex, waist circumference, and creatinine are independent variables
  3. bFor IL-6 and IL-10, Tobit regressions were used for the significance test and regular linear regressions to calculate the beta coefficients