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Table 2 Published cases of intracranial neuroendocrine tumors of primary origin

From: Primary neuroendocrine tumor of the pineal gland: a case report

Source Intracranial Location Age (y.) Sex Treatment Overall survival Cause of death
Hakar et al. Pineal parenchyma 35 Female Subtotal resection
Cisplatin, etoposide, sunitinib
Craniospinal irradiation
Died 26 months following diagnosis Cancer progression
Liu et al. Sella/hypothalamic 39 Female Resection Died three months following diagnosis Cancer progression, too unwell to receive radiotherapy
Liu et al. Anterior cranial fossa 40 Female Resection At time of publication, patient alive, but undisclosed timeline -
Reed et al. Intraventricular, third ventricle 34 Female Resection
Intensity modulated radiation therapy
Cisplatin and etoposide
Followed for five years with no recurrence
Recurrence 10 years after initial diagnosis, died 2 months after
Complications of hydrocephalus secondary to recurrence
Ibrahim et al. Skull base, level of jugular foramen 29 Female Monthly somatostatin injections
Patient declined radiotherapy
Followed for one year with stable disease -
Hood et al. Left cavernous sinus 61 Female Subtotal resection
Fractionated external beam radiation therapy
Followed for 7.5 years with stable disease -
Deshaies et al. Dural-based, compressing right frontal lobe 79 Female Resection
Octreotide
Died 6 weeks after diagnosis Unknown complications
Cao et al. Multiple lesions, left parietal convexity, right occipital parietal convexity, left frontal convexity, left cerebral falx, right temporal lobe 56 Female Resection of three lesions
Whole brain and tumor bed radiotherapy
Temozolomide with recombinant human endostatin
Followed for 10 months with stable disease -
Porter et al. Right cerebellopontine angle of posterior fossa 62 Male Subtotal resection At time of publication, 5-year survival -
Our study Pineal parenchyma 53 Male Subtotal resection
Temozolomide
Craniospinal irradiation
Died 18 months after diagnosis Cancer progression