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Table 2 Published cases of intracranial neuroendocrine tumors of primary origin

From: Primary neuroendocrine tumor of the pineal gland: a case report

Source

Intracranial Location

Age (y.)

Sex

Treatment

Overall survival

Cause of death

Hakar et al.

Pineal parenchyma

35

Female

Subtotal resection

Cisplatin, etoposide, sunitinib

Craniospinal irradiation

Died 26 months following diagnosis

Cancer progression

Liu et al.

Sella/hypothalamic

39

Female

Resection

Died three months following diagnosis

Cancer progression, too unwell to receive radiotherapy

Liu et al.

Anterior cranial fossa

40

Female

Resection

At time of publication, patient alive, but undisclosed timeline

-

Reed et al.

Intraventricular, third ventricle

34

Female

Resection

Intensity modulated radiation therapy

Cisplatin and etoposide

Followed for five years with no recurrence

Recurrence 10 years after initial diagnosis, died 2 months after

Complications of hydrocephalus secondary to recurrence

Ibrahim et al.

Skull base, level of jugular foramen

29

Female

Monthly somatostatin injections

Patient declined radiotherapy

Followed for one year with stable disease

-

Hood et al.

Left cavernous sinus

61

Female

Subtotal resection

Fractionated external beam radiation therapy

Followed for 7.5 years with stable disease

-

Deshaies et al.

Dural-based, compressing right frontal lobe

79

Female

Resection

Octreotide

Died 6 weeks after diagnosis

Unknown complications

Cao et al.

Multiple lesions, left parietal convexity, right occipital parietal convexity, left frontal convexity, left cerebral falx, right temporal lobe

56

Female

Resection of three lesions

Whole brain and tumor bed radiotherapy

Temozolomide with recombinant human endostatin

Followed for 10 months with stable disease

-

Porter et al.

Right cerebellopontine angle of posterior fossa

62

Male

Subtotal resection

At time of publication, 5-year survival

-

Our study

Pineal parenchyma

53

Male

Subtotal resection

Temozolomide

Craniospinal irradiation

Died 18 months after diagnosis

Cancer progression